Publications of Alfred Wittinghofer

Rosnizeck, I. C.; Graf, T.; Spoerner, M.; Tränkle, J.; Filchtinski, D.; Herrmann, C.; Gremer, L.; Vetter, I. R.; Wittinghofer, A.; König, B. et al.; Kalbitzer, H. R.: Stabilizing a Weak Binding State for Effectors in the Human Ras Protein by Cyclen Complexes. Angewandte Chemie International Edition 49 (22), 1, pp. 3830 - 3833 (2010)

Rosnizeck, I. C.; Graf, T.; Spoerner, M.; Tränkle, J.; Filchtinski, D.; Herrmann, C.; Gremer, L.; Vetter, I. R.; Wittinghofer, A.; König, B. et al.; Kalbitzer, H. R.: Stabilisierung eines niederaffinen Zustands für Effektoren im menschlichen Ras-Protein durch Cyclenkomplexe. Angewandte Chemie 122 (22), 1, pp. 3918 - 3922 (2010)

Sot, B.; Kötting, C.; Deaconescu, D.; Suveyzdis, Y.; Gerwert, K.; Wittinghofer, A.: Unravelling the mechanism of dual-specificity GAPs. EMBO Journal 29 (7), 1, pp. 1205 - 1214 (2010)

Meyer, S.; Böhme, S.; Krüger, A.; Steinhoff, H.-J.; Klare, J. P.; Wittinghofer, A.: Kissing G Domains of MnmE Monitored by X-Ray Crystallography and Pulse Electron Paramagnetic Resonance Spectroscopy. PLoS Biology 7 (10), 1, p. e1000212 (2009)

Meyer, S.; Wittinghofer, A.; Versées, W.: G-Domain Dimerization Orchestrates the tRNA Wobble Modification Reaction in the MnmE/GidA Complex. Journal of Molecular Biology 392 (4), 1, pp. 910 - 922 (2009)

Veltel, S.; Wittinghofer, A.: RPGR and RP2: targets for the treatment of X-linked retinitis pigmentosa? Expert Opinion on Therapeutic Targets 13 (10), 1, pp. 1239 - 1251 (2009)

Sirajuddin, M.; Farkasowsky, M.; Zent, E.; Wittinghofer, A.: GTP-induced conformational changes in septins and implications for function. Proceedings of the National Academy of Sciences of the United States of America 106 (39), 1, pp. 16592 - 16597 (2009)

Yaman, E.; Gasper, R.; Koerner, C.; Wittinghofer, A.; Tazebay, U. H.: RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange. FEBS Journal 276 (16), 1, pp. 4607 - 4616 (2009)

Gasper, R.; Meyer, S.; Gotthardt, K.; Sirajuddin, M.; Wittinghofer, A.: It takes two to tango: regulation of G proteins by dimerization. Nature Reviews Molecular Cell Biology 10 (6), 1, pp. 423 - 429 (2009)

Ottmann, C.; Weyand, M.; Sassa, T.; Inoue, T.; Kato, N.; Wittinghofer, A.; Oecking, C.: A Structural Rationale for Selective Stabilization of Anti-tumor Interactions of 14-3-3 proteins by Cotylenin A. Journal of Molecular Biology 386 (4), 1, pp. 913 - 919 (2009)

Uhlenbrock, K.; Weiwad, M.; Wetzker, R.; Fischer, G.; Wittinghofer, A.; Rubio, I.: Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway. FEBS Letters 583 (6), 1, pp. 965 - 970 (2009)

Lammers, M.; Meyer, S.; Kühlmann, D.; Wittinghofer, A.: Specificity of Interactions between mDia Isoforms and Rho Proteins. Journal of Biological Chemistry 283 (50), 1, pp. 35236 - 35246 (2008)

Rehmann, H.; Brüning, M.; Berghaus, C.; Schwarten, M.; Köhler, K.; Stocker, H.; Stoll, R.; Zwartkruis, F. J.; Wittinghofer, A.: Biochemical characterisation of TCTP questions its function as a guanine nucleotide exchange factor for Rheb. FEBS Letters 582 (20), 1, pp. 3005 - 3010 (2008)

Gremer, L.; Gilsbach, B.; Ahmadian, M. R.; Wittinghofer, A.: Fluoride complexes of oncogenic Ras mutants to study the Ras-RasGAP interaction. Biological Chemistry 389 (9), 1, pp. 1163 - 1171 (2008)

Gotthardt, K.; Weyand, M.; Kortholt, A.; van Haastert, P. J. M.; Wittinghofer, A.: Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. The EMBO Journal 27 (16), 1, pp. 2239 - 2249 (2008)

Veltel, S.; Kravchenko, A.; Shehab, I.; Wittinghofer, A.: Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3-effector-GAP complex. FEBS Letters 582 (17), 1, pp. 2501 - 2507 (2008)

Meyer, S.; Scrima, A.; Versées, W.; Wittinghofer, A.: Crystal Structures of the Conserved tRNA-Modifying Enzyme GidA: Implications for Its Interaction with MnmE and Substrate. Journal of Molecular Biology 380 (3), 1, pp. 532 - 547 (2008)

Schrader, N.; Koerner, C.; Koessmeier, K.; Bangert, J. A.; Wittinghofer, A.; Stoll, R.; Vetter, I. R.: The Crystal Structure of the Ran-Nup153ZnF2 Complex: a General Ran Docking Site at the Nuclear Pore Complex. Structure 16, 1, pp. 1116 - 1125 (2008)

Gasper, R.; Thomas, C.; Ahmadian, M. R.; Wittinghofer, A.: The Role of the Conserved Switch II Glutamate in Guanine Nucleotide Exchange Factor-Mediated Nucleotide Exchange of GTP-Binding Proteins. Journal of Molecular Biology 379 (1), 1, pp. 51 - 63 (2008)

Kötting, C.; Kallenbach, A.; Suveyzdis, Y.; Wittinghofer, A.; Gerwert, K.: The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy. Proceedings of the National Academy of Sciences of the United States of America 105 (17), 1, pp. 6260 - 6265 (2008)