Publications of Alfred Wittinghofer

Rehmann, H.; Das, J.; Knipscheer, P.; Wittinghofer, A.; Bos, J. L.: Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature 439, 1, pp. 625 - 628 (2006)

Kühnel, K.; Veltel, S.; Schlichting, I.; Wittinghofer, A.: Crystal Structure of the Human Retinitis Pigmentosa 2 Protein and Its Interaction with Arl3. Structure 14 (2), 1, pp. 367 - 378 (2006)

Wittinghofer, A.: Phosphoryl transfer in Ras proteins, conclusive or elusive? Trends in Biochemical Sciences 31 (1), 1, pp. 20 - 23 (2006)

Lammers, M.; Rose, R.; Scrima, A.; Wittinghofer, A.: The regulation of mDia1 by autoinhibition and its release by Rho●GTP. The EMBO Journal 24, 1, pp. 4176 - 4187 (2005)

Berken, A.; Thomas, C.; Wittinghofer, A.: A new family of RhoGEFs activates the Rop molecular switch in plants. Nature 436 (7054), 1, pp. 1176 - 1180 (2005)

Farkasovsky, M.; Herter, P.; Voss, B.; Wittinghofer, A.: Nucleotide binding and filament assembly of recombinant yeast septin complexes. Biological Chemistry 386 (7), 1, pp. 643 - 656 (2005)

Hanzal-Bayer, M.; Linari, M.; Wittinghofer, A.: Properties of the Interaction of Arf-like Protein 2 with PDEδ. Journal of Molecular Biology 350 (5), 1, pp. 1074 - 1082 (2005)

Rose, R.; Weyand, M.; Lammers, M.; Ishizaki, T.; Ahmadian, M. R.; Wittinghofer, A.: Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature 435 (7041), 1, pp. 513 - 518 (2005)

Wohlgemuth, S.; Kiel, C.; Krämer, A.; Serrano, L.; Wittinghofer, F.; Herrmann, C.: Recognizing and Defining True Ras Binding Domains I: Biochemical Analysis. Journal of Molecular Biology 348 (3), 1, pp. 741 - 758 (2005)

Roßbach, M.; Daumke, O.; Klinger, C.; Wittinghofer, A.; Kaufmann, M.: Crystal structure of THEP1 from the hyperthermophile Aquifex aeolicus: a variation of the RecA fold. BMC Structural Biology 5 (7), 1, pp. 1 (separate pagination) - 20 (separate pagination) (2005)

Rocks, O.; Peyker, A.; Kahms, M.; Verveer, P. J.; Koerner, C.; Lumbierres, M.; Kuhlmann, J.; Waldmann, H.; Wittinghofer, A.; Bastiaens, P. I. H.: An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms. Science 307 (5716), 1, pp. 1746 - 1752 (2005)

Kiel, C.; Wohlgemuth, S.; Rousseau, F.; Schymkowitz, J.; Ferkinghoff-Borg, J.; Wittinghofer, F.; Serrano, L.: Recognizing and Defining True Ras Binding Domains II: In Silico Prediction Based on Homology Modelling and Energy Calculations. Journal of Molecular Biology 348 (3), 1, pp. 759 - 775 (2005)

Gail, R.; Frank, R.; Wittinghofer, A.: Systematic Peptide Array-based Delineation of the Differential β-Catenin Interaction with Tcf4, E-Cadherin, and Adenomatous Polyposis Coli. Journal of Biological Chemistry 280 (8), 1, pp. 7107 - 7117 (2005)

Rose, R.; Wittinghofer, A.; Weyand, M.: The purification and crystallization of mDia1 in complex with RhoC. Acta Crystallographica Section F. Structural Biology and Crystallization Communications 61 (2), 1, pp. 225 - 227 (2005)

Spoerner, M.; Nuehs, A.; Ganser, P.; Herrmann, C.; Wittinghofer, A.; Kalbitzer, H. R.: Conformational States of Ras Complexed with the GTP Analogue GppNHp or GppCH2p: Implications for the Interaction with Effector Proteins. Biochemistry 44 (6), 1, pp. 2225 - 2236 (2005)

Scrima, A.; Vetter, I. R.; Armengod, M. E.; Wittinghofer, A.: The structure of the TrmE GTP-binding protein and its implications for tRNA modification. EMBO Journal 24 (1), 1, pp. 23 - 33 (2005)

Kühnel, K.; Jarchau, T.; Wolf, E.; Schlichting, I.; Ulrich, W.; Wittinghofer, A.; Strelkov, S. V.: The VASP tetramerization domain is a right-handed coiled coil based on a 15-residue repeat. Proceedings of the National Academy of Sciences of the United States of America 101 (49), 1, pp. 17027 - 17032 (2004)

Spoerner, M.; Wittinghofer, A.; Kalbitzer, H. R.: Perturbation of the conformational equilibria in Ras by selective mutations as studied by ³¹P NMR spectroscopy. FEBS Letters 578 (3), 1, pp. 305 - 310 (2004)

Chakrabarti, P. P.; Suveyzdis, Y.; Wittinghofer, A.; Gerwert, K.: Fourier Transform Infrared Spectroscopy on the Rap·RapGAP Reaction, GTPase Activation without an Arginine Finger. Journal of Biological Chemistry 279 (44), 1, pp. 46226 - 46233 (2004)

Soulère, L.; Aldrich, C.; Daumke, O.; Gail, R.; Kissau, L.; Wittinghofer, A.; Waldmann, H.: Synthesis of GTP-Derived Ras Ligands. ChemBioChem 5 (10), 1, pp. 1448 - 1453 (2004)