Publications of Alfred Wittinghofer

Waldmann, H.; Schelhaas, M.; Nagele, E.; Kuhlmann, J.; Wittinghofer, A.; Schroeder, H.; Silvius, J.: Chemoenzymatic synthesis of fluorescent N-ras lipopeptides and their use in membrane localization studies in vivo. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 36 (20), pp. 2238 - 2241 (1997)

Wittinghofer, A.: Signaling mechanistics: Aluminum fluoride for molecule of the year. Current Biology 7 (11), 1, pp. R682 - R685 (1997)

Wittinghofer, A.; Nassar, N.: How Ras-related proteins talk to their effectors. Trends in biochemical sciences 21 (12), 1, pp. 488 - 491 (1996)

Geyer, M.; Schweins, T.; Herrmann, C.; Prisner, T.; Wittinghofer, A.; Kalbitzer, H. R.: Conformational transitions in p21^ras and in its complexes with the effector protein Raf-RBD and the GTPase activating protein GAP. Biochemistry 35 (32), 1, pp. 10308 - 10320 (1996)

McCormick, F.; Wittinghofer, A.: Interactions between Ras proteins and their effectors. Current Opinion in Biotechnology 7 (4), 1, pp. 449 - 456 (1996)

Scheffzek, K.; Lautwein, A.; Kabsch, W.; Ahmadian, M. R.; Wittinghofer, A.: Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras. Nature 384, pp. 591 - 596 (1996)

Wittinghofer, A.: Deciphering the alphabet of G proteins: The structure of the α, β, γ heterotrimer. Structure 4 (4), 1, pp. 357 - 361 (1996)

Ligeti, E.; Pizon, V.; Wittinghofer, A.; Gierschik, P.; Jakobs, K. H.: GTPASE ACTIVITY OF SMALL GTP-BINDING PROTEINS IN HL-60 MEMBRANES IS STIMULATED BY ARACHIDONIC-ACID. EUROPEAN JOURNAL OF BIOCHEMISTRY 216 (3), pp. 813 - 820 (1993)

Stouten, P. F. W.; Sander, C.; Wittinghofer, A.; Valencia, A.: HOW DOES THE SWITCH-II REGION OF G-DOMAINS WORK. FEBS LETTERS 320 (1), pp. 1 - 6 (1993)

Wittinghofer, A.: FROM EF-TU TO P21^RAS AND BACK AGAIN. CURRENT BIOLOGY 3 (12), pp. 874 - 876 (1993)

Foley, C. K.; Pedersen, L. G.; Charifson, P. S.; Darden, T. A.; Wittinghofer, A.; Pai, E. F.; Anderson, M. W.: SIMULATION OF THE SOLUTION STRUCTURE OF THE H-RAS P21-GTP COMPLEX. BIOCHEMISTRY 31 (21), pp. 4951 - 4959 (1992)

Gideon, P.; John, J.; Frech, M.; Lautwein, A.; Clark, R.; Scheffler, J. E.; Wittinghofer, A.: MUTATIONAL AND KINETIC ANALYSES OF THE GTPASE-ACTIVATING PROTEIN (GAP)-P21 INTERACTION - THE C-TERMINAL DOMAIN OF GAP IS NOT SUFFICIENT FOR FULL ACTIVITY. MOLECULAR AND CELLULAR BIOLOGY 12 (5), pp. 2050 - 2056 (1992)

Goody, R. S.; Pai, E. F.; Schlichting, I.; Rensland, H.; Scheidig, A. J.; Franken, S.; Wittinghofer, A.: STUDIES ON THE STRUCTURE AND MECHANISM OF H-RAS P21. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES 336 (1276), pp. 3 - & (1992)

Hahnel, C.; Gottmann, K.; Wittinghofer, A.; Lux, H. D.: P21^RAS ONCOGENE PROTEIN SELECTIVELY INCREASES LOW-VOLTAGE-ACTIVATED CA²⁺ CURRENT DENSITY IN EMBRYONIC CHICK DORSAL ROOT GANGLION NEURONS. EUROPEAN JOURNAL OF NEUROSCIENCE 4 (4), pp. 361 - 368 (1992)

Mistou, M.-Y.; Jacquet, E.; Poullet, P.; Rensland, H.; Gideon, P.; Schlichting, I.; Wittinghofer, A.; Parmeggiani, A.: MUTATIONS OF HA-RAS P21 THAT DEFINE IMPORTANT REGIONS FOR THE MOLECULAR MECHANISM OF THE SDC25 C-DOMAIN, A GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR. EMBO JOURNAL 11 (7), pp. 2391 - 2397 (1992)

Müller, O.; Frech, M.; Gideon, P.; Wittinghofer, A.; Schwarz, M. K.: DIFFERENCES IN GTPASE-ACTIVATING PROTEIN-ACTIVITY BETWEEN LIVER-TUMORS AND NORMAL LIVER-TISSUE IN MICE. ONCOGENE 7 (7), pp. 1407 - 1412 (1992)

Scheidig, A. J.; Pai, E. F.; Schlichting, I.; Corrie, J.; Reid, G. P.; Wittinghofer, A.; Goody, R. S.; Liljas, A.; Moffat, K.: TIME-RESOLVED CRYSTALLOGRAPHY ON H-RAS P21 [AND DISCUSSION]. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES 340 (1657), pp. 263 - & (1992)

Serth, J.; Weber, W.; Frech, M.; Wittinghofer, A.; Pingoud, A.: BINDING OF THE H-RAS P21 GTPASE ACTIVATING PROTEIN BY THE ACTIVATED EPIDERMAL GROWTH-FACTOR RECEPTOR LEADS TO INHIBITION OF THE P21 GTPASE ACTIVITY IN VITRO. BIOCHEMISTRY 31 (28), pp. 6361 - 6365 (1992)

Wiesmüller, L.; Wittinghofer, A.: EXPRESSION OF THE GTPASE ACTIVATING DOMAIN OF THE NEUROFIBROMATOSIS TYPE-1 (NF1) GENE IN ESCHERICHIA-COLI AND ROLE OF THE CONSERVED LYSINE RESIDUE. JOURNAL OF BIOLOGICAL CHEMISTRY 267 (15), pp. 10207 - 10210 (1992)

Wolber, V.; Maeda, K.; Schumann, R.; Brandmeier, B.; Wiesmüller, L.; Wittinghofer, A.: A UNIVERSAL EXPRESSION-PURIFICATION SYSTEM BASED ON THE COILED-COIL INTERACTION OF MYOSIN HEAVY-CHAIN. BIO-TECHNOLOGY 10 (8), pp. 900 - 904 (1992)