Publications of Malte Gersch

Wendrich, K.; Gallant, K.; Recknagel, S.; Petroulia, S.; Haque Kazi, N.; Hane, J. A.; Führer, S.; Bezstarosti, K.; O'Dea, R.; Demmers, J. et al.; Gersch, M.: Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53. Nature Chemical Biology (2024)

Schmidt, M.; Grethe, C.; Recknagel, S.; Kipka, G.-M.; Klink, N.; Gersch, M.: N-Cyanopiperazines as Specific Covalent Inhibitors of the Deubiquitinating Enzyme UCHL1. Angewandte Chemie, International Edition in English (2024)

Zhao, Z.; O'Dea, R.; Kaz, N.; Gersch, M.: Native Semisynthesis of Isopeptide-Linked Substrates for Specificity Analysis of Deubiquitinases and Ubl Proteases. Journal of the American Chemical Society (2023)

O'Dea, R.; Kazi, N.; Hoffmann-Benito, A.; Zhao, Z.; Rechnagel, S.; Wendrich, K.; Janning, P.; Gersch, M.: Molecular basis for ubiquitin/Fubi cross-reactivity in USP16 and USP36. Nature Chemical Biology (2023)

Grethe, C.; Schmidt, M.; Kipka, G.-M.; O'Dea, R.; Gallant, K.; Janning, P.; Gersch, M.: Structural basis for specific inhibition of the deubiquitinase UCHL1. Nature Communications 13 (2022)

Ruiz, E. J.; Pinto-Fernandez, A.; Turnball, A. P.; Lan, L.; Charlton, T. M.; Scott, H. C.; Damianou, A.; Vere, G.; Riising, E. M.; Da Costa, C. et al.; Krajewski, W. W.; Guerin, D.; Kearns, J. D.; Ioannidis , S.; Katz, M.; McKinnon, C.; O´Connell, J.; Moncaut, N.; Rosewell, I.; Nye, E.; Jones, N.; Heride, C.; Gersch, M.; Wu, M.; Dinsmore, C. J.; Hammonds, T. R.; Kim, S.; Komander, D.; Urbe, S.; Clague, M. J.; Kessler, B. M.; Behrens, A.: USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma. eLife, 10:e71596, pp. 1 - 23 (2021)

Rusilowicz-Jones, E. V.; Jardine, J.; Kallinos, A.; Pinto-Fernandez, A.; Guenther, F.; Giurrandino, M.; Barone, F. G.; McCarron, K.; Burke, C. J.; Murad , A. et al.; Martinez, A.; Marcassa , E.; Gersch, M.; Buckmelter, A. J.; Kayser-Bricker, K. J.; Lamoliatte , F.; Gajbhiye , A.; Davis , S.; Scott, H. C.; Murphy, E.; England , K.; Mortiboys, H.; Komander, D.; Trost, M.; Kessler, B. M.; Ioannidis, S.; Ahlijanian, M. K.; Urbé, S.; Clague, M. J.: USP30 sets a trigger threshold for PINK1–PARKIN amplification of mitochondrial ubiquitylation. Life Science Alliance 3 (8), e202000768, pp. 1 - 14 (2020)

Gersch, M.; Wagstaff, J. L.; Toms, A. V.; Graves, B.; Freund, S. M. V.; Komander, D.: Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity. Molecular Cell 74 (3), pp. 436 - 451 (2019)

Mirko, S.: Design, synthesis and biological evaluation of tool compounds for the cellular investigation of deubiquitinases. Dissertation, TU Dortmund, Dortmund (2023)