Publications of Andrea Musacchio

Schweighofer, J.; Mulay, B.; Hoffmann, I.; Vogt, D.; Pesenti, M.; Musacchio, A.: Interactions with multiple inner kinetochore proteins determine mitotic localization of FACT. Journal of Cell Biology (2025)

Lim, W. M.; Chew, W.-X.; Esposito Verza, A.; Pesenti, M.; Musacchio, A.; Surrey, T.: Regulation of minimal spindle midzone organization by mitotic kinases. Nature Communications (2024)

Hedtfeld, M.; Musacchio, A.: Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and in human cells. STAR Protoc. (2024)

Conti, D.; Esposito Verza, A.; Pesenti, M.; Cmentowski, V.; Vetter, I. R.; Pan, D.; Musacchio, A.: Role of protein kinase PLK1 in the epigenetic maintenance of centromeres. Science (2024)

Pleuger, R.; Cozma, C.; Hohoff, S.; Denkhaus, C.; Dudziak, A.; Kaschani, F.; Kaiser, M.; Musacchio, A.; Vetter, I. R.; Musacchio, A. et al.; Westermann, S.: Microtubule end-on attachment maturation regulates Mps1 association with its kinetochore receptor. Current Biology (2024)

Hedtfeld, M.; Dammers, A.; Koerner, C.; Musacchio, A.: A validation strategy to assess the role of phase separation as a determinant of macromolecular localization. Molecular Cell (2024)

Polley, S.; Raisch, T.; Ghetti, S.; Körner, M.; Terbeck, M.; Gräter, F.; Raunser, S.; Aponte-Santamaria, C. A.; Vetter, I. R.; Musacchio, A.: Structure of the human KMN complex and implications for regulation of its assembly. Nature Structural & Molecular Biology (2024)

Cmentowski, V.; Ciossani, G.; d'Amico, E.; Wohlgemuth, S.; Owa, M.; Dynlacht, B.; Musacchio, A.: RZZ-Spindly and CENP-E form an integrated platform to recruit dynein to the kinetochore corona. The EMBO Journal (2023)

Polley, S.; Müschenborn, H.; Terbeck, M.; De Antoni, A.; Vetter, I. R.; Dogterom, M.; Musacchio, A.; Volkov, V. A.; Huis in´t Veld, P. J.: Stable kinetochore-microtubule attachment requires loop-dependent Ndc80-Ndc80 binding. EMBO Journal (2023)

Chen, C.; Piano, V.; Alex, A.; Hahn, S. J.; Huis in´t Veld, P. J.; Roy, B.; Fergle, D.; Musacchio, A.; Joglekar, A. P.: The structural flexibility of MAD1 facilitates the assembly of the Mitotic Checkpoint Complex. Nature Communications 14 (1) (2023)

Di Cesare, E.; Moroni, S.; Bartoli, J.; Damizia, M.; Giubettini, M.; Krenn, V.; Musacchio, A.; Lavia, P.: Aurora B SUMOylation Is Restricted to Centromeres in Early Mitosis and Requires RANBP2. Cells 12 (2023)

d'Amico, E.; Ud Din Ahmad, M.; Cmentowski, V.; Girbig, M.; Müller, F.; Wohlgemuth, S.; Brockmeyer, A.; Maffini, S.; Vetter, I. R.; Carter, A. P. et al.; Perrakis, A.; Musacchio, A.: Conformational transitions of the Spindly adaptor underlie its interaction with Dynein and Dynactin. The Journal of Cell Biology: JCB 221 (2022)

Schwietert, F.; Volkov, V. A.; Huis in´t Veld, P. J.; Dogterom, M.; Musacchio, A.; Kierfeld, J.: Strain stiffening of Ndc80 complexes attached to microtubule plus ends. Biophysical Journal (2022)

Celestino, R.; Gama, J. B.; Castro-Rodrigues, A. F.; Barbosa, D. B.; Rocha, H.; d'Amico, E.; Musacchio, A.; Carvalho, A. X.; Morais-Cabral, J. H.; Gassmann, R.: JIP3 interacts with dynein and kinesin-1 to regulate bidirectional organelle transport. The Journal of Cell Biology: JCB (2022)

Pesenti, M.; Raisch, T.; Conti, D.; Walstein, K.; Hoffmann, I.; Vogt, D.; Prumbaum, D.; Vetter, I. R.; Raunser, S.; Musacchio, A.: Structure of the human inner kinetochore CCAN complex and its significance for human centromere organization. Molecular Cell 82, pp. 1 - 19 (2022)

Raisch, T.; Ciossani, G.; d'Amico, E.; Cmentowski, V.; Carmignani, S.; Maffini, S.; Merino, F.; Wohlgemuth, S.; Vetter, I. R.; Raunser, S. et al.; Musacchio, A.: Structure of the RZZ complex and molecular basis of Spindly-driven corona assembly at human kinetochores. The EMBO Journal, e110411, pp. 1 - 22 (2022)

Musacchio, A.: On the role of phase separation in the biogenesis of membraneless compartments. The EMBO Journal, e109952, pp. 1 - 20 (2022)

Martin, I. M.; Aponte-Santamaría , C.; Schmidt, L.; Hedtfeld, M.; Iusupov, A.; Musacchio, A.; Gräter, F.: Phosphorylation tunes elongation propensity and cohesiveness of INCENP's intrinsically disordered region. Journal of Molecular Biology (London) 434 (1), 167387, pp. 1 - 37 (2021)

van den Boom, J.; Kueck, A. F.; Kravic, B.; Müschenborn, H.; Giesing, M.; Pan, D.; Kaschani, F.; Kaiser, M.; Musacchio, A.; Meyer, H.: Targeted substrate loop insertion by VCP/p97 during PP1 complex disassembly. Nature Structural and Molecular Biology 28 (12), pp. 964 - 971 (2021)

Huis in´t Veld, P. J.; Wohlgemuth, S.; Koerner, C.; Müller, F.; Janning, P.; Musacchio, A.: Reconstitution and use of highly active human CDK1:Cyclin-B:CKS1 complexes. Protein Science 31 (2), pp. 528 - 537 (2021)