Roger Goody

Roger Goody

Emeritus Group, Physical Biochemistry


PubMed Liste>


Goebel L, Kirschner T, Koska S, Rai A, Janning P, Maffini S, Vatheuer H, Czodrowski P, Goody RS, Müller MP, Rauh D (2023). Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors. Elife


Rai A, Singh AK, Bleimling N, Posern G, Vetter IR, Goody RS (2022). Rep15 interacts with several Rab GTPases and has a distinct fold for a Rab effector. Nat Commun.

Akbarzadeh M, Flegel J, Patil S, Shang E, Narayan R, Buchholzer M, Kazemein Jasemi NS, Grigalunas M, Krzyzanowski A, Abegg D, Shuster A, Potowski M, Karatas H, Karageorgis G, Mosaddeghzadeh N, Zischinsky ML, Merten C, Golz C, Brieger L, Strohmann C, Antonchick AP, Janning P, Adibekian A, Goody RS, Ahmadian MR, Ziegler S, Waldmann H. (2022). The Pseudo-Natural Product Rhonin Targets RHOGDI. Angew Chem Int Ed Engl.


Goebel L, Müller MP, Goody RS, Rauh D (2020). KRasG12C inhibitors in clinical trials: a short historical perspective. RSC Med Chem.

Rai A, Bleimling N, Vetter IR, Goody RS (2020). The mechanism of activation of the actin binding protein EHBP1 by Rab8 family members. Nat Commun


Goody RS, Müller MP, Rauh D (2019). Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules. Cell Chem Biol
doi: 10.1016/j.chembiol.2019.07.005

Morris MC, Mery J, Heitz F, Goody RS, Divita G (2019). Correction: A new potent HIV-1 reverse transcriptase inhibitor: A synthetic peptide derived from the interface subunit domains. J Biol Chem.
doi: 10.1074/jbc.AAC119.008640.


Jeganathan S, Müller MP, Ali I, Goody RS (2018). Assays for Nucleotide Competitive Reversible and Irreversible Inhibitors of Ras GTPases. Biochemistry
doi: 10.1021/acs.biochem.8b00234

Ali I, Eu S, Koch D, Bleimling N, Goody RS, Müller MP. (2018). Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae. Acta Crystallogr F Struct Biol Commun.
doi: 10.1107/S2053230X18005915.


Rai A, Goody RS, Müller MP (2017). Multivalency in Rab effector interactions Small GTPases
doi: 10.1080/21541248.2016.1265700.

üller MP, Goody RS (2017). Molecular control of Rab activity by GEFs, GAPs and GDI. Small GTPases
doi: 10.1080/21541248.2016.1276999.


Goody RS, Müller MP, Wu YW (2016). Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport. Biol Chem
doi: 10.1515/hsz-2016-0274.

Rai A, Oprisko A, Campos J, Fu Y, Friese T, Itzen A, Goody RS, Gazdag EM, M ller MP (2016). bMERB domains are bivalent Rab8 family effectors evolved by gene duplication. Elife
doi:' 10.7554/eLife.18675.

Cromm PM, Spiegel J, K chler P, Dietrich L, Kriegesmann J, Wendt M, Goody RS, Waldmann H, Grossmann TN (2016). Protease-Resistant and Cell-Permeable Double-Stapled Peptides Targeting the Rab8a GTPase. ACS Chem Biol 11(8):2375-82.
doi:" 10.1021/acschembio.6b00386.

Mueller MP, Goody RS (2016). Review: Ras GTPases and myosin: Qualitative conservation and quantitative diversification in signal and energy transduction. Biopolymers 105(8):422-30.
doi: 10.1002/bip.22840.

Koch D, Rai A, Ali I, Bleimling N, Friese T, Brockmeyer A, Janning P, Goud B, Itzen A, Müller MP,Goody RS (2016). A pull-down procedure for the identification of unknown GEFs for small GTPases. Small GTPases 93-106
doi: 10.1080/21541248.2016.1156803.


Wiegandt D, Vieweg S, Hofmann F, Koch D, Li F, Wu YW, Itzen A, Muller MP, and Goody RS (2015). Locking GTPases covalently in their functional states. Nature communications 6, 7773.
doi: 10.1038/ncomms8773.


Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szegő ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, Giorgini F, Outeiro TF, Zweckstetter M (2014). α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiol Dis 70:149-61.
doi: 10.1016/j.nbd.2014.06.018.

Gavriljuk K, Schartner J, Itzen A, Goody RS, Gerwert K, K tting C (2014). Reaction mechanism of adenylyltransferase DrrA from Legionella pneumophila elucidated by time-resolved fourier transform infrared spectroscopy. J Am Chem Soc 136(26):9338-45.
doi: 10.1021/ja501496d.

Gazdag EM, Schöbel S, Shkumatov AV, Goody RS, Itzen A (2014). The structure of the N-terminal domain of the Legionella protein SidC. J Struct Biol 186(1):188-94.
doi: 10.1016/j.jsb.2014.02.003.

Spiegel J, Cromm PM, Itzen A, Goody RS, Grossmann TN, Waldmann H (2014). Direct targeting of Rab-GTPase-effector interactions. Angew Chem Int Ed Engl 53(9):2498-503.
doi: 10.1002/anie.201308568.

Li F, Yi L, Zhao L, Itzen A, Goody RS, Wu YW (2014). The role of the hypervariable C-terminal domain in Rab GTPases membrane targeting. Proc Natl Acad Sci U S A 111(7):2572-7.
doi: 10.1073/pnas.1313655111.

Goody RS (2014). How not to do kinetics: examples involving GTPases and guanine nucleotide exchange factors. FEBS J 281(2):593-600.
doi: 10.1111/febs.12551.


Sadian Y, Gatsogiannis C, Patasi C, Hofnagel O, Goody RS, Farkasovský M, Raunser S (2013). The role of Cdc42 and Gic1 in the regulation of septin filament formation and dissociation. Elife 2:e01085.
doi: 10.7554/eLife.01085.

Guo Z, Hou X, Goody RS, Itzen A (2013). Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB. J Biol Chem 288(45):32466-74.
doi: 10.1074/jbc.M113.498329.

Gavriljuk K, Itzen A, Goody RS, Gerwert K, Kötting C (2013). Membrane extraction of Rab proteins by GDP dissociation inhibitor characterized using attenuated total reflection infrared spectroscopy. Proc Natl Acad Sci U S A 110(33):13380-5.
doi: 10.1073/pnas.1307655110.

Kapoor S, Werkm ller A, Goody RS, Waldmann H, Winter R (2013). Pressure modulation of Ras-membrane interactions and intervesicle transfer. J Am Chem Soc 135(16):6149-56.
doi: 10.1021/ja312671j.

Goody RS (2013). How bacteria choose phosphate. Angew Chem Int Ed Engl 52(9):2406-7.
doi: 10.1002/anie.201209376.

Blumer J, Rey J, Dehmelt L, Mazel T, Wu YW, Bastiaens P, Goody RS, and Itzen A (2013). RabGEFs are a major determinant for specific Rab membrane targeting. J Cell Biol 200, 287-300.

Gazdag EM, Streller A, Haneburger I, Hilbi H, Vetter IR, Goody RS, and Itzen A (2013). Mechanism of Rab1b deactivation by the Legionella pneumophila GAP LepB. Embo Rep 14, 199-205.
doi: 10.1038/embor.2012.211

Gogolin L, Schroeder H, Itzen A, Goody RS, Niemeyer CM, Becker CF (2013). Protein-DNA arrays as tools for detection of protein-protein interactions by mass spectrometry. Chembiochem 14(1):92-9.
doi: 10.1002/cbic.201200597.

Goody RS, Itzen A (2013). Modulation of small GTPases by Legionella. Curr Top Microbiol Immunol 376:117-33.
doi: 10.1007/82_2013_340.

K hnke M, Delon C, Hastie ML, Nguyen UT, Wu YW, Waldmann H, Goody RS, Gorman JJ, Alexandrov K (2013). Rab GTPase prenylation hierarchy and its potential role in choroideremia disease. PLoS One8(12):e81758.
doi: 10.1371/journal.pone.0081758.


Gavriljuk K, Gazdag EM, Itzen A, Kötting C, Goody RS, Gerwert K (2012). Catalytic mechanism of a mammalian Rab·RabGAP complex in atomic detail. Proc Natl Acad Sci U S A 109(52):21348-53.
doi: 10.1073/pnas.1214431110.

Bl mer J, Wu YW, Goody RS, Itzen A (2012). Specific localization of Rabs at intracellular membranes. Biochem Soc Trans 40(6):1421-5.
doi: 10.1042/BST20120225.

Kalinin S, Peulen T, Sindbert S, Rothwell PJ, Berger S, Restle T, Goody RS, Gohlke H, Seidel CA (2012). A toolkit and benchmark study for FRET-restrained high-precision structural modeling. Nat Methods 9(12):1218-25.
doi: 10.1038/nmeth.2222.

Yi L, Chen YX, Lin PC, Schr der H, Niemeyer CM, Wu YW, Goody RS, Triola G, Waldmann H (2012). Direct immobilization of oxyamine-modified proteins from cell lysates. Chem Commun (Camb) 48(88):10829-31.
doi: 10.1039/c2cc35237k.

Müller MP, Shkumatov AV, Oesterlin LK, Schoebel S, Goody PR, Goody RS, Itzen A (2012). Characterization of enzymes from Legionella pneumophila involved in reversible adenylylation of Rab1 protein. J Biol Chem 287(42):35036-46.
doi: 10.1074/jbc.M112.396861.

Stigter EA, Guo Z, Bon RS, Wu YW, Choidas A, Wolf A, Menninger S, Waldmann H, Blankenfeldt W,Goody RS (2012). Development of selective, potent RabGGTase inhibitors. J Med Chem 55(19):8330-40.
doi: 10.1021/jm300624s.

Tnimov Z, Guo Z, Gambin Y, Nguyen UT, Wu YW, Abankwa D, Stigter A, Collins BM, Waldmann H,Goody RS, Alexandrov K (2012). Quantitative analysis of prenylated RhoA interaction with its chaperone, RhoGDI. J Biol Chem 287(32):26549-62.
doi: 10.1074/jbc.M112.371294.

Deraeve C, Guo Z, Bon RS, Blankenfeldt W, DiLucrezia R, Wolf A, Menninger S, Stigter EA, Wetzel S, Choidas A, Alexandrov K, Waldmann H, Goody RS, Wu YW (2012). Psoromic acid is a selective and covalent Rab-prenylation inhibitor targeting autoinhibited RabGGTase. J Am Chem Soc 134(17):7384-91.
doi: 10.1021/ja211305j.

Oesterlin LK, Goody RS, Itzen A (2012). Posttranslational modifications of Rab proteins cause effective displacement of GDP dissociation inhibitor. Proc Natl Acad Sci U S A 109(15):5621-6.
doi: 10.1073/pnas.1121161109

Goody PR, Heller K, Oesterlin LK, M ller MP, Itzen A, Goody RS (2012). Reversible phosphocholination of Rab proteins by Legionella pneumophila effector proteins. EMBO J 31(7):1774-84.
doi: 10.1038/emboj.2012.16.

Hagemann N, Hou X, Goody RS, Itzen A, Erdmann KS (2012). Crystal structure of the Rab binding domain of OCRL1 in complex with Rab8 and functional implications of the OCRL1/Rab8 module for Lowe syndrome. Small GTPases 3(2):107-10.
doi: 10.4161/sgtp.19380.

Das D, Tnimov Z, Nguyen UT, Thimmaiah G, Lo H, Abankwa D, Wu Y, Goody RS, Waldmann H, Alexandrov K (2012). Flexible and general synthesis of functionalized phosphoisoprenoids for the study of prenylation in vivo and in vitro. Chembiochem 13(5):674-83.
doi: 10.1002/cbic.201100733


Wu YW, Goody RS, Alexandrov K (2011). Intein-mediated construction of a library of fluorescent Rab GTPase probes. Chembiochem 12(18):2813-21.
doi: 10.1002/cbic.201100377.

Schoebel S, Cichy AL, Goody RS, Itzen A (2011). Protein LidA from Legionella is a Rab GTPase supereffector. Proc Natl Acad Sci U S A108(44):17945-50.
doi: 10.1073/pnas.1113133108.

Michaelis L, Menten ML, Johnson KA, Goody RS (2011). The original Michaelis constant: translation of the 1913 Michaelis-Menten paper. Biochemistry 50(39):8264-9.
doi: 10.1021/bi201284u.

Smit C, Bl mer J, Eerland MF, Albers MF, M ller MP, Goody RS, Itzen A, Hedberg C (2011). Efficient synthesis and applications of peptides containing adenylylated tyrosine residues. Angew Chem Int Ed Engl 50(39):9200-4.
doi: 10.1002/anie.201103203.

Yi L, Sun H, Itzen A, Triola G, Waldmann H, Goody RS, Wu YW (2011). One-pot dual-labeling of a protein by two chemoselective reactions. Angew Chem Int Ed Engl 50(36):8287-90.
doi: 10.1002/anie.201100840.

Itzen A, Goody RS (2011) Covalent coercion by Legionella pneumophila. Cell Host Microbe10(2):89-91.
doi: 10.1016/j.chom.2011.08.002.

Yu S, Vit A, Devenish S, Mahanty HK, Itzen A, Goody RS, Blankenfeldt W (2011). Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria. BMC Struct Biol 11:33.
doi: 10.1186/1472-6807-11-33.

K, Blankenfeldt W,Goody RS, Waldmann H (2011). Structure-guided development of selective RabGGTase inhibitors. Bon RS, Guo Z, Stigter EA, Wetzel S, Menninger S, Wolf A, Choidas A, Alexandrov Angew Chem Int Ed Engl 50(21):4957-61.
doi: 10.1002/anie.201101210.

Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody RS, Erdmann KS, Itzen A (2011). A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1. EMBO J 30(8):1659-70.
doi: 10.1038/emboj.2011.60.

Itzen A, Blankenfeldt W, Goody RS (2011). Adenylylation: renaissance of a forgotten post-translational modification. Trends Biochem Sci 36(4):221-8.
doi: 10.1016/j.tibs.2010.12.004.

Wixler V, Wixler L, Altenfeld A, Ludwig S, Goody RS, Itzen A (2011). Identification and characterisation of novel Mss4-binding Rab GTPases. Biol Chem 392(3):239-48.
doi: 10.1515/BC.2011.022.

Itzen A, Goody RS (2011). GTPases involved in vesicular trafficking: structures and mechanisms. Semin Cell Dev Biol 22(1):48-56.
doi: 10.1016/j.semcdb.2010.10.003.

Goody RS, Müller MP, Schoebel S, Oesterlin LK, Blümer J, Peters H, Blankenfeldt W, Itzen A (2011). The versatile Legionella effector protein DrrA. Commun Integr Biol 4(1):72-4.
doi: 10.4161/cib.4.1.13857.

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