Dr. Michael Grigalunas
Project Group Leader, Chemical Biology
Natural products represent Nature’s exploration of chemical space through evolution. Our lab is interested in exploring biologically-relevant chemical space through the chemical evolution of natural product structure guided by the concept of pseudo-natural products. This entails the synthetic combination of natural product fragments to arrive at scaffolds that are natural product-like but are not accessible through existing biosynthetic pathways. Through phenotypic assays and morphological profiling, we hope to identify pseudo-natural products with unexpected or new bioactivities.
Grigalunas M, Burhop A, Zinken S, Pahl A, Gally JM, Wild N, Mantel Y, Sievers S, Foley DJ, Scheel R, Strohmann C, Antonchick AP, Waldmann H (2021). Natural product fragment combination to performance-diverse pseudo-natural products. Nat Commun.
Grigalunas M, Burhop A, Christoforow A, Waldmann H (2020). Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery Curr. Opin. Chem. Biol