Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1

Choreography of rapid actin filament disassembly by coronin, cofilin, and AIP1

Raunser Group. Cell (2025) [more]
Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1mRNA splicing

Harnessing indole scaffolds to identify small-molecule IRE1α inhibitors modulating XBP1mRNA splicing

Wu Group. Nature Communications (2025) [more]
Myeloperoxidase transforms chromatin into neutrophil extracellular traps

Myeloperoxidase transforms chromatin into neutrophil extracellular traps

Raunser Group. Nature (2025) [more]
Microscopy image of kinetochore coronas (green) during cell division.

 A validation strategy to assess the role of phase separation as a determinant of macromolecular localization

Musacchio Group. Science Advances (2025) [more]
Cryo-EM structure of PMCA bound to neuroplastin (NPTN).

Molecular mechanism of 1 ultra-fast and phospholipid-controlled ion transport by plasma membrane Ca2+-ATPases

Raunser Group. Nature (2025) [more]
Polo-like kinase 1 (PLK1)–phosphatase connection in mitosis. Schematic of the kinetochore (KT) and its regulation by mitotic kinases. KNL1, ZWINT, the four-subunit MIS12 complex (Mis12C) and the four-subunit NDC80 complex (Ndc80C) are core components of the microtubule (MT)-binding interface of the KT. They also act as docking sites for proteins involved in error correction and the spindle assembly checkpoint (SAC). Abbreviation: AURKA/B, Aurora A/B kinase; CDK, cyclin-dependent kinase; MELT, Met-Glu-Leu-Thr.

Decoding the language of PLK1 docking motifs and activation mechanisms

Musacchio Group. Trends Cell Biol. (2025) [more]
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