Philippe Bastiaens was born 1963 in Den Helder (Netherlands). He studied biochemistry and molecular physics at the University of Wageningen (Netherlands) and at the University of Georgia (USA) and the University of Illinois (USA). In 1988 he received his diploma (with distinction) in “Engineering in Molecular Sciences” from the University of Wageningen, where from 1989 – 1992 he earned his doctorate in biochemistry with distinction.

From 1993 to 1996 he was postdoctoral fellow at the Max Planck Institute for Biophysical Chemistry in Göttingen in the research group of Thomas Jovin. During this time he became interested in spectroscopic techniques for the investigation of protein interactions in living cells. In 1997 he became a group leader at the Imperial Cancer Research Fund in London. In 2000 he returned to Germany to take on a group leader position at the renowned European Molecular Biology Laboratory (EMBL) in Heidelberg. At the same time he was a professor at the University of Amsterdam, where he focused on the microscopic analysis of the dynamics of biochemical processes in cells.

In 2006 he became director of the Department of Systemic Cell Biology at the Max Planck Institute of Molecular Physiology in Dortmund. Since then, he has been teaching cell biology and systems biology at TU Dortmund University.

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Vita

Complete Vita   

Education

1992
PhD in biochemistry (with distinction): “Fluorescence relaxation spectroscopy: light on dynamical structures of flavoprotein”
Department of Biochemistry, Agricultural University, Wageningen (NL)

1988
Degree of Engineering in Molecular Sciences (with distinction): “Specialisation:
biochemistry and molecular physics”
Department of Biochemistry, Agricultural University, Wageningen (NL)

Current Positions

since 2006
Director
Department for Systemic Cell Biology, MPI of Molecular Physiology, Dortmund (Germany)
since 2007
Full Professor
Faculty of Chemistry and Chemical Biology, Technische Universität Dortmund, Dortmund (Germany)

Previous Positions

2000 – 2006
Group leader
European Molecular Biology Laboratory, Heidelberg, Germany
Professor
University of Amsterdam, Amsterdam (NL)

1997 – 2000
Group leader
Cell Biophysics Laboratory, Imperial Cancer Research Fund

1993 – 1996
Postdoc
Department of Molecular Biology, MPI for Biophysical Chemistry, Göttingen (Germany)

Fellowships and Awards

2013
ERC Advanced Grant

2010
Leica Scientific Forum Speaker in “Advances in Life Science”
Sydney/Melbourne/Brisbane (Australia)

since 2008
Elected EMBO Member

1993
Prize for Biochemistry and Molecular Biology of the Netherlands Society for Biochemistry and Molecular Biology (NVBMB)

1992 – 1993
Research fellow
Royal Dutch Academy of Sciences, Royal Dutch Academy of Sciences, University of Wageningen, Wageningen (The Netherlands)


Selected Publications 2013 - 2018

List of Publications 07/2019   

Baumdick M, Gelléri M, Uttamapinant C, Beránek V, Chin JW, Bastiaens PIH (2018). A conformational sensor based on genetic code expansion reveals an autocatalytic component in EGFR activation. Nat Commun
doi: 10.1038/s41467-018-06299-7.

Stanoev A, Mhamane A, Schuermann KC, Grecco HE, Stallaert W, Baumdick M, Brüggemann Y, Joshi MS, Roda-Navarro P, Fengler S, Stockert R, Roßmannek L, Luig J, Koseska A, Bastiaens PIH (2018). Interdependence between EGFR and Phosphatases Spatially Established by Vesicular Dynamics Generates a Growth Factor Sensing and Responding Network. Cell Syst
doi: 10.1016/j.cels.2018.06.006.

Stallaert W, Brüggemann Y, Sabet O, Baak L, Gattiglio M, Bastiaens PIH (2018). Contact inhibitory Eph signaling suppresses EGF-promoted cell migration by decoupling EGFR activity from vesicular recycling. Sci Sig
doi: 10.1126/scisignal.aat0114.

Tsutsumi R, Harizanova J, Stockert R, Schröder K, Bastiaens PIH, Neel BG. (2017). Assay to visualize specific protein oxidation reveals spatio-temporal regulation of SHP2. Nat Commun 8(1):466
doi: 10.1038/s41467-017-00503-w.

Antonios D. Konitsiotis, Lisaweta Roßmannek, Angel Stanoev, Malte Schmick & Philippe I.H. Bastiaens (2017). Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation. Nat Commun 8:114
doi: 10.1038/s41467-017-00116-3.

Papke B, Murarka S, Vogel HA, Martín-Gago P, Kovacevic M, Truxius DC, Fansa EK, Ismail S, Zimmermann G, Heinelt K, Schultz-Fademrecht C, Al Saabi A, Baumann M, Nussbaumer P, Wittinghofer A, Waldmann H, Bastiaens PI (2016). Identification of pyrazolopyridazinones as PDEδ inhibitors. Nat Commun 7:11360. doi: 10.1038/ncomms11360.
doi: 10.1038/ncomms11360.

Masip ME, Huebinger J, Christmann J, Sabet O, Wehner F, Konitsiotis A, Fuhr GR, Bastiaens PI (2016). Reversible cryo-arrest for imaging molecules in living cells at high spatial resolution. Nat Methods. 13(8):665-72.
doi: 10.1038/nmeth.3921

Sabet O, Stockert R, Xouri G, Brüggemann Y, Stanoev A, Bastiaens PI (2015). Ubiquitination switches EphA2 vesicular traffic from a continuous safeguard to a finite signaling mode. Nat Commun 6:8047.
doi: 10.1038/ncomms9047.

Ibach J, Radon Y, Gelleri M, Sonntag MH, Brunsveld L, Bastiaens PI, Verveer PJ (2015). Single Particle Tracking Reveals that EGFR Signaling Activity Is Amplified in Clathrin-Coated Pits. PLoS One 10(11):e0143162.
doi: 10.1371/journal.pone.0143162.

Baumdick M, Brüggemann Y, Schmick M, Xouri G, Sabet O, Davis L, Chin JW, Bastiaens PI (2015). EGF-dependent re-routing of vesicular recycling switches spontaneous phosphorylation suppression to EGFR signaling. ELife 4: e12223.
doi: 10.7554/eLife.12223.

Roda-Navarro P, Bastiaens PI (2014). Dynamic recruitment of protein tyrosine phosphatase PTPD1 to EGF stimulation sites potentiates EGFR activation. PLoS One 9(7):e103203.
doi: 10.1371/journal.pone.0103203.

Schmick M, Vartak N, Papke B, Kovacevic M, Truxius DC, Rossmannek L, Bastiaens PI (2014). KRas localizes to the plasma membrane by spatial cycles of solubilization, trapping and vesicular transport. Cell 157(2):459-71.
doi: 10.1016/j.cell.2014.02.051.

Vartak N, Papke B, Grecco HE, Rossmannek L, Waldmann H, Hedberg C, Bastiaens PIH (2014). Autocatalytic APT depalmitoylation maintains spatial organization of palmitoylated membrane proteins. Biophys J 106(1):93-105
doi: 10.1016/j.bpj.2013.11.024.

Zimmermann G, Papke B, Ismail S, Vartak N, Chandra A, Hoffmann M, Hahn SA, Triola G, Wittinghofer A, Bastiaens PI, Waldmann H (2013). Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature 30;497(7451):638-42
doi: 10.1038/nature12205.

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