Publications of Alfred Wittinghofer

Veltel, S.; Gasper, R.; Eisenacher, E.; Wittinghofer, A.: The retinitis pigmentosa 2 gene product is a GTPase-activating protein for Arf-like 3. Nature Structural & Molecular Biology 15, 1, pp. 373 - 380 (2008)

Berken, A.; Wittinghofer, A.: Structure and function of Rho-type molecular switches in plants. Plant Physiology and Biochemistry 46 (3), 1, pp. 380 - 393 (2008)

Scrima, A.; Thomas, C.; Deaconescu, D.; Wittinghofer, A.: The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. EMBO Journal 27, 1, pp. 1145 - 1153 (2008)

Sirajuddin, M.; Farkasovsky, M.; Hauer, F.; Kühlmann, D.; Macara, I. G.; Weyand, M.; Stark, H.; Wittinghofer, A.: Structural insight into filament formation by mammalian septins. Nature 449 (7160), 1, pp. 311 - 315 (2007)

Bos, J. L.; Rehmann, H.; Wittinghofer, A.: GEFs and GAPs: Critical Elements in the Control of Small G Proteins. Cell 129 (5), 1, pp. 865 - 877 (2007)

Koller-Eichhorn, R.; Marquardt, T.; Gail, R.; Wittinghofer, A.; Kostrewa, D.; Kutay, U.; Kambach, C.: Human OLA1 Defines an ATPase Subfamily in the Obg Family of GTP-binding Proteins. Journal of Biological Chemistry 282 (27), 1, pp. 19928 - 19937 (2007)

Chakrabarti, P. P.; Daumke, O.; Suveyzdis, Y.; Kötting, C.; Gerwert, K.; Wittinghofer, A.: Insight into Catalysis of a Unique GTPase Reaction by a Combined Biochemical and FTIR Approach. Journal of Molecular Biology 367 (4), 1, pp. 983 - 995 (2007)

Ottmann, C.; Marco, S.; Jaspert, N.; Marcon, C.; Schauer, N.; Weyand, M.; Vandermeeren, C.; Duby, G.; Boutry, M.; Wittinghofer, A. et al.; Rigaud, J.-L.; Oecking, C.: Structure of a 14-3-3 Coordinated Hexamer of the Plant Plasma Membrane H⁺-ATPase by Combining X-Ray Crystallography and Electron Cryomicroscopy. Molecular Cell 25 (3), 1, pp. 427 - 440 (2007)

Ottmann, C.; Yasmin, L.; Weyand, M.; Veesenmeyer, J. L.; Diaz, M. H.; Palmer, R. H.; Francis, M. S.; Hauser, A. R.; Wittinghofer, A.; Hallberg, B.: Phosphorylation-independent interaction between 14-3-3 and exoenzyme S: from structure to pathogenesis. EMBO Journal 26 (3), 1, pp. 902 - 913 (2007)

Thomas, C.; Fricke, I.; Scrima, A.; Berken, A.; Wittinghofer, A.: Structural Evidence for a Common Intermediate in Small G Protein-GEF Reactions. Molecular Cell 25 (1), 1, pp. 141 - 149 (2007)

Rehmann, H.; Wittinghofer, A.; Bos, J. L.: Capturing cyclic nucleotides in action: snapshots from crystallographic studies. Nature Reviews Molecular Cell Biology 8, 1, pp. 63 - 73 (2007)

Brunsveld, L.; Kuhlmann, J.; Alexandrov, K.; Wittinghofer, A.; Goody, R. S.; Waldmann, H.: Lipidated Ras and Rab Peptides and Proteins - Synthesis, Structure, and Function. Angewandte Chemie International Edition 45 (40), 1, pp. 6622 - 6646 (2006)

Brunsveld, L.; Kuhlmann, J.; Alexandrov, K.; Wittinghofer, A.; Goody, R. S.; Waldmann, H.: Lipidierte Ras- und Rab-Peptide und -Proteine: Synthese, Struktur und Funktion. Angewandte Chemie 118 (40), 1, pp. 6774 - 6798 (2006)

Kötting, C.; Blessenohl, M.; Suveyzdis, Y.; Goody, R. S.; Wittinghofer, A.; Gerwert, K.: A phosphoryl transfer intermediate in the GTPase reaction of Ras in complex with its GTPase-activating protein. Proceedings of the National Academy of Sciences of the USA 103 (38), 1, pp. 13911 - 13916 (2006)

Gasper, R.; Scrima, A.; Wittinghofer, A.: Structural Insights into HypB, a GTP-binding Protein That Regulates Metal Binding. Journal of Biological Chemistry 281 (37), 1, pp. 27492 - 27502 (2006)

Korholt, A.; Rehmann, H.; Kae, H.; Bosgraaf, L.; Keizer-Gunnink, I.; Weeks, G.; Wittinghofer, A.; Van Haastert, P. J. M.: Characterization of the GbpD-activated Rap1 Pathway Regulating Adhesion and Cell Polarity in Dictyostelium discoideum. Journal of Biological Chemistry 281 (33), 1, pp. 23367 - 23376 (2006)

Scrima, A.; Wittinghofer, A.: Dimerisation-dependent GTPase reaction of MnmE: how potassium acts as GTPase-activating element. EMBO Journal 25 (12), 1, pp. 2940 - 2951 (2006)

Thomas, C.; Weyand, M.; Wittinghofer, A.; Berken, A.: Purification and crystallization of the catalytic PRONE domain of RopGEF8 and its complex with Rop4 from Arabidopsis thaliana. Acta Crystallographica Section F Structural Biology and Crystallization Communications F62 (Part 6), 1, pp. 607 - 610 (2006)

Kupzig, S.; Deaconescu, D.; Bouyoucef, D.; Walker, S. A.; Liu, Q.; Polte, C. L.; Daumke, O.; Ishizaki, T.; Lockyer, P. J.; Wittinghofer, A. et al.; Cullen, P. J.: GAP1 Family Members Constitute Bifunctional Ras and Rap GTPase-activating Proteins. Journal of Biological Chemistry 281 (15), 1, pp. 9891 - 9900 (2006)

Ghosh, A.; Praefcke, G. J. K.; Renault, L.; Wittinghofer, A.; Herrmann, C.: How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature 440 (7080), 1, pp. 101 - 104 (2006)