Kamal Kumar

Kamal Kumar

Synthesis designs to create structurally diverse and natural-product based ring-systems


ORCID Liste>


Ciualla MG, Zimmermann S & Kumar K (2018). Cascade synthesis strategies targeting biologically intriguing indole polycycles Org Biomol Chem
doi: 10.1039/C8OB02620C

Kumar K, Xin X, Zimmermann S, Flegl J, Otte F, Knauer L, Strohmann C, Ziegler S (2018). Unravelling Synthesis and Chemistry of Stable, Acyclic and Double-Deficient 1,3-Butadienes: An endo-selective Diels-Alder Route to Hedgehog Pathway Inhibitors. Chemistry
doi: 10.1002/chem.201805823.

Lee YC, Kumar K, Waldmann H (2018). Ligand-directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems. Angewandte Chem Int Ed
doi: 10.1002/anie.201710247

Sankar MG, Roy S, Ngoc Tran TT, Wittstein K, Bauer JO, Strohmann C, Ziegler S, Kumar K (2018). Scaffold Diversity Synthesis Delivers Complex, Structurally, and Functionally Distinct Tetracyclic Benzopyrones. Chemistry Open
doi: 10.1002/open.201800025

Kumar K, Waldmann H (2018). Nature Inspired Small Molecules for Chemical Biology Isr Ch Chem
doi: 10.1002/ijch.201800105

Lee YC, Kumar K, Waldmann H (2018). Ligand-directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems. Angewandte Chemi Int Ed
doi: 10.1002/anie.201710247

Sankar MG, Roy S, Ngoc Tran TT, Wittstein K, Bauer JO, Strohmann C, Ziegler S, Kumar K (2018). Scaffold Diversity Synthesis Delivers Complex, Structurally, and Functionally Distinct Tetracyclic Benzopyrones. Chemistry Open
doi: 10.1002/open.201800025

Lee YC, Kumar K (2018). Gold(I) Catalyzed Enyne Cycloisomerization – A Roadmap to Privileged Heterocyclic Scaffolds. Isr Ch Chem
doi: 10.1002/anie.201710247


Lee YC, Kumar K, Waldmann H (2017). Ligand-directed Divergent Synthesis of Carbo- and Heterocyclic Ring Systems. Angew Chem Int Ed Engl
doi: 10.1002/anie.201710247

Kumar K, Jayakumar S, Louven K, Strohmann C (2017). A Tunable and Enantioselective Hetero-Diels-Alder Reaction Provides Access to Distinct Piperidinoyl Spirooxindoles. Angew Chem Int Ed Engl
doi: 10.1002/anie.201708355.

Pahl A, Waldmann H, Kumar K. (2017). Exploring Natural Product Fragments for Drug and Probe Discovery. Chimia (Aarau)
doi: doi: 10.2533/chimia.2017.653.

Garcia-Castro M, Annamalai M,Golz C, Strohman C, Kumar K (2017). Stereoselective Synthesis of Trisubstituted Epoxides Marks the Route to Chiral Building Blocks with Quaternary Centers. European Journal of Organic Chemistry
doi: 10.1002/ejoc.201701148.

Sheremet M, Kapoor S, Schröder P, Kumar K, Ziegler S and Waldmann H (2017). Natural Product Withanolide-Inspired Small molecules as Potent Inhibitors of Wnt Signaling. Chembiochem
doi: 10.1002/cbic.201700260.

Annamalai M, Hristeva S, Bielska M, Ortega R, Kumar K (2017). Highly Stereoselective Synthesis of a Compound Collection Based on the Bicyclic Scaffolds of Natural Products. Molecules
doi: 10.3390/molecules22050827.

Lee YC, Patil S, Golz C, Strohmann C, Ziegler S, Kumar K, Waldmann H (2017). A ligand-directed divergent catalytic approach to establish structural and functional scaffold diversity. Nat Commun 8:14043
doi: 10.1038/ncomms14043.

Laraia L, Ohsawa K, Konstantinidis G, Robke L, Wu YW, Kumar K, Waldmann H (2017). Discovery of Novel Cinchona-Alkaloid-Inspired Oxazatwistane Autophagy Inhibitors. Angew Chem Int Ed Engl 56(8):2145-2150.
doi: 10.1002/anie.201611670.


Kesava-Reddy N, Golz C, Strohmann C. & Kumar K. (2016). Silver(I)-Catalyzed Enantioselective [3+2]-Cycloaddition Reaction of α-Silylimines: A Facile Route to Quaternary-Carbon Rich Scaffolds Chemistry 22 (51), 18373–18377
doi: 10.1002/chem.201604793

Sankar MG, Garcia-Castro M., Golz C, Strohmann, C. & Kumar K. (2016). Engaging Allene Derived Zwitterions in an Unprecedented Mode of Asymmetric [3+2]-Annulation Reaction. Angew Chem Int Ed
doi: 10.1002/anie.201603936.

Schröder P, Bauer JO, Strohmann C, Kumar K, Waldmann H (2016). Synthesis of an Iridoid-Inspired Compound Collection and Discovery of Autophagy Inhibitors. J Org Chem
doi: 10.1021/acs.joc.6b01185

Garcia-Castro M, Zimmermann S, Sankar MG, Kumar K (2016). Scaffold Diversity Synthesis and Its Application in Probe and Drug Discovery. Angew Chem Int Ed Engl55(27):7586-605.
doi: 10.1002/anie.201508818.

Danda A, Kesava-Reddy N, Golz C, Strohmann C & Kumar K (2016). Asymmetric Roadmap to Diverse Polycyclic Benzopyrans via 2 Phosphine-Catalyzed Enantioselective [4 + 2]-Annulation Reaction. Org. Lett
doi: 10.1021/acs.orglett.6b01030.

Perez-Galan P, Waldmann H, Kumar K. (2016). Building polycyclic indole scaffolds via gold(I)-catalyzed intra- and inter-molecular cyclization reactions of 1,6-enynes Tetrahedron 72(60), 3647–3652
doi: 10.1016/j.tet.2016.03.020

Sankar MG, Carcia-Castro M, Golz C, Strohmann C and Kumar K. (2016). l -Isoleucine derived bifunctional phosphine catalyses asymmetric [3 + 2]-annulation of allenyl-esters and -ketones with ketimines RSC Adv 6, 56537-56543
doi: 10.1039/C6RA12387B


Schröder P, Förster T, Kleine S, Becker C, Richters A, Ziegler S, Rauh D, Kumar K, Waldmann H (2015). Neuritogenic militarinone-inspired 4-hydroxypyridones target the stress pathway kinase MAP4K4. Angew Chem Int Ed Engl54(42):12398-403.
doi: 10.1002/anie.201501515.

Meiß R, Kumar K, Waldmann H (2015). Divergent Gold(I)-Catalyzed Skeletal Rearrangements of 1,7-Enynes. Chemistry21(39):13526-30.
doi: 10.1002/chem.201502843.

Sankar MG, Mantilli L, Bull J, Giordanetto F, Bauer JO, Strohmann C, Waldmann H, Kumar K (2015). Stereoselective synthesis of a natural product inspired tetrahydroindolo[2,3-a]-quinolizine compound library. Bioorg Med Chem 23(11):2614-20.
doi: 10.1016/j.bmc.2015.01.019.

Murali A, Medda F, Winkler M, Giordanetto F, Kumar K (2015). Branching cascades provide access to two amino-oxazoline compound libraries. Bioorg Med Chem 23(11):2656-65.
doi: 10.1016/j.bmc.2015.01.009.

Švenda J, Sheremet M, Kremer L, Maier L, Bauer JO, Strohmann C, Ziegler S, Kumar K, Waldmann H (2015). Biology-oriented synthesis of a withanolide-inspired compound collection reveals novel modulators of hedgehog signaling. Angew Chem Int Ed Engl 54(19):5596-602.
doi: 10.1002/anie.201500112.

Danda A, Kumar K, Waldmann H (2015). A general catalytic reaction sequence to access alkaloid-inspired indole polycycles. Chem Commun (Camb) 51(35):7536-9.
doi: 10.1039/c5cc01555c.

Garcia-Castro M, Kremer L, Reinkemeier CD, Unkelbach C, Strohmann C, Ziegler S, Ostermann C. & Kumar K (2015). De novo branching cascades for structural and functional diversity in small molecules. Nat Commun 6:6516
doi: 10.1038/ncomms7516.

Kumar K. (2015). Kamal Kumar. Angew Chem Int Ed Engl
doi: 10.1002/anie.201411798


Eschenbrenner-Lux V, Kumar K, Waldmann H (2014). The asymmetric hetero-Diels-Alder reaction in the syntheses of biologically relevant compounds. Angew Chem Int Ed Engl53(42):11146-57.
doi: 10.1002/anie.201404094.

Kolundžić F, Murali A, Pérez-Galán P, Bauer JO, Strohmann C, Kumar K, Waldmann H (2014). A cyclization-rearrangement cascade for the synthesis of structurally complex chiral gold(I)-aminocarbene complexes. Angew Chem Int Ed Engl 53(31):8122-6.
doi: 10.1002/anie.201403651.

Wang Y, Bauer JO, Strohmann C, & Kumar K (2014). A Bioinspired Catalytic Oxygenase Cascade to Generate Complex Oxindoles. Angew Chem Int Ed 53, 7514-18.
doi: 10.1002/anie.201403415

Eschenbrenner-Lux V, Küchler P, Ziegler S, Kumar K, Waldmann H (2014). An enantioselective inverse-electron-demand imino Diels-Alder reaction. Angew Chem Int Ed Engl 53(8):2134-7.
doi: 10.1002/anie.201309022.


Dakas P-Y, Parga JA, Höing S, Schöler HR, Sterneckert J, Kumar K & Waldmann H (2013). Discovery of Neuritogenic Compound Classes Inspired by Natural Products. Angew Chem Int Ed 52, 9576 –95813.

doi: 10.1002/anie.201302045

Eschenbrenner-Lux V, Dückert H, Khedkar V, Bruss H, Waldmann H, Kumar K (2013). Cascade syntheses routes to the centrocountins. Chemistry 19(7):2294-304.
doi: 10.1002/chem.201203714.

Sankar MG, Garcia-Castro M, Wang Y, Kumar K. (2013).A Facile Dipolar Entry to Diverse Dihydro-1H-1,2,4-Triazoles Asian Journal of Organic Chemistry 2(8),646–649
doi: 10.1002/ajoc.201300120


Baskar B, Wittstein K, Sankar MG, Khedkar V, Schürmann M, Kumar K (2012). Stereoselective cascade double-annulations provide diversely ring-fused tetracyclic benzopyrones. Org Lett 14(23):5924-7.
doi: 10.1021/ol3028412.

Lachance H, Wetzel S, Kumar K, Waldmann H (2012). Charting, navigating, and populating natural product chemical space for drug discovery. J Med Chem 55(13):5989-6001.
doi: 10.1021/jm300288g.

Wittstein K, Garcia AB, Schürmann M, Kumar K (2012).Exploring α-Chromonyl Nitrones as 1,5-Dipoles Synlett (2): 227-232
doi: 10.1055/s-0031-1290070

Dückert H, Pries V, Khedkar V, Menninger S, Bruss H, Bird AW, Maliga Z, Brockmeyer A, Janning P, Hyman A, Grimme S, Schürmann M, Preut H, Hübel K, Ziegler S, Kumar K, Waldmann H (2011). Natural product-inspired cascade synthesis yields modulators of centrosome integrity. Nat Chem Biol 8(2):179-84.
doi: 10.1038/nchembio.758.


Wetzel S, Bon RS, Kumar K, Waldmann H (2011). Biology-oriented synthesis. Angew Chem Int Ed Engl 50(46):10800-26.
doi: 10.1002/anie.201007004.

Eberhardt L, Kumar K, Waldmann H (2011). Exploring and exploiting biologically relevant chemical space. Curr Drug Targets 12(11):1531-46.
doi: 10.2174/138945011798109482

Wittstein K, Kumar K, Waldmann H (2011). Gold(I)-catalyzed synthesis of benzoxocines by an 8-endo-dig cyclization. Angew Chem Int Ed Engl50(39):9076-80.
doi: 10.1002/anie.201103832.

Liu W, Khedkar V, Baskar B, Schürmann M, Kumar K (2011). Branching cascades: a concise synthetic strategy targeting diverse and complex molecular frameworks. Angew Chem Int Ed Engl 50(30):6900-5.
doi: 10.1002/anie.201102440.

Dückert H, Khedkar V, Waldmann H, Kumar K (2011). Lewis base catalyzed [4+2] annulation of electron-deficient chromone-derived heterodienes and acetylenes. Chemistry17(18):5130-7.
doi: 10.1002/chem.201003572.

Baskar B, Dakas PY, Kumar K (2011). Natural product biosynthesis inspired concise and stereoselective synthesis of benzopyrones and related scaffolds. Org Lett 13(8):1988-91.
doi: 10.1021/ol200389p.

Waldmann H, Bruss H, Dückert H, Kumar K (2011).Synthesis of novel electron-deficient chromone-fused dienes via phosphine catalyzed [4+2] annulation Tetrahedron Letters 52(17), 2265-2267
doi: 10.1016/j.tetlet.2011.01.151

vor 2011

Waldmann H, Eberhardt L, Wittstein K, Kumar K (2010). Silver catalyzed cascade synthesis of alkaloid ring systems: concise total synthesis of fascaplysin, homofascaplysin C and analogues. Chem Commun (Camb) 46(25):4622-4.
doi: 10.1039/c001350a.

Kumar K, Waldmann H (2009). Synthesis of natural product inspired compound collections. Angew Chem Int Ed Engl 48(18):3224-42.
doi: 10.1002/anie.200803437.

Waldmann H, Karunakar GV, Kumar K (2008). Gold(III)-mediated aldol condensations provide efficient access to nitrogen heterocycles. Org Lett 10(11):2159-62.
doi: 10.1021/ol8005634.

Waldmann H, Kühn M, Liu W, Kumar K (2008). Reagent-controlled domino synthesis of skeletally-diverse compound collections. Chem Commun (Camb) (10):1211-3.
doi: 10.1039/b717635j.

Waldmann H, Khedkar V, Dückert H, Schürmann M, Oppel IM, Kumar K (2008). Asymmetric synthesis of natural product inspired tricyclic benzopyrones by an organocatalyzed annulation reaction. Angew Chem Int Ed Engl 47(36):6869-72.
doi: 10.1002/anie.200802413.

Khedkar V, Liu W, Dückert H, Kumar K (2010).Efficient and Atom-Economic Synthesis of α-Substituted β-Chromonyl-α,β-unsaturated Carbonyls through Molecular Rearrangement Synlett (3): 403-406  
doi: 10.1055/s-0029-1219176

Kapur A, Kumar K, Singh L, Singh P, Elango M, Subramanian V, Gupta V, Kanwal P, Ishar MPS (2009).Domino routes to substituted benzoindolizines: tandem reorganization of 1,3-dipolar cycloadducts of nitrones with allenic esters/ketones and alternative cycloaddition palladium catalyzed cyclization pathway Tetrahedron 65(23), 4593 4603
doi: 10.1016/j.tet.2009.03.076

Kaiser M, Wetzel K, Kumar K, Waldmann H (2008).Biology-inspired synthesis of compound libraries Mol. Life Sci. 65: 1186. 
doi: 10.1007/s00018-007-7492-1

Barun O, Kumar K, Sommer S, Langerak A, Mayer TU, M ller O, Waldmann H (2005).Natural Product-Guided Synthesis of a Spiroacetal Collection Reveals Modulators of Tubulin Cytoskeleton Integrity European Journal of Organic Chemistry
doi: 10.1002/ejoc.200500605

Harkal S, Kumar K, Michalik D, Zapf A, Jackstell R, Rataboul F, Riermeier T, Monsees A, Beller M (2004).An efficient catalyst system for diaryl ether synthesis from aryl chlorides Tetrahedron Letters
doi: 10.1016/j.tetlet.2005.03.033

Michalik D, Kumar K, Zapf A, Tillack A, Arlt M, Heinrich T, Beller M (2004).A short and efficient synthesis of N-aryl- and N-heteroaryl-N -(arylalkyl)piperazines Tetrahedron Letters
doi: 10.1016/j.tetlet.2004.01.066

Kumar K, Kapur A, Ishar MPS (2000).Unusual [8 + 2] Annelation in the Reactions of Allenic Ester/Ketone-Derived 1,3-Dipoles with Tropone Org. Lett.
doi: 10.1021/ol000007l

Ishar MPS, Kumar K (1999).Tandem reorganisation of 1,3-dipolar cycloadducts of C-(4-oxo-4H[1]benzopyran-3-yl)-N-phenylnitrone and allenic esters, leading to novel functionalized benzo[b]indolizines Tetrahedron Letters
doi: 10.1016/S0040-4039(98)80051-8

Ishar MPS, Kumar K , Singh R (1998). Thermal rearrangements of C-(4-Oxo-4H[1]benzopyran-3-yl)-N-phenylnitrone-a route to novel quinolino[2,3-b]chroman-12-ones Tetrahedron Letters
doi: 10.1016/S0040-4039(98)01362-8

Kumar K , Jolly RS (1998). The catalysis of intramolecular [4+2] cycloaddition reaction by palladium complexes Tetrahedron Letters
doi: 10.1016/S0040-4039(98)00353-0 

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