Homeostatic Control of Meiotic Prophase Checkpoint Function by Pch2 and Hop1

Raina VB, Vader G (2020) Current Biology

doi: https://doi.org/10.1016/j.cub.2020.08.064.

Here, the Vader lab provide insight into the roles of Pch2, a generally conserved AAA+ ATPASE, and its connection to Hop1, a HORMA domain-containing client protein, in the meiotic prophase checkpoint.

Pch2 and Hop1 collaborate to mediate general meiotic prophase checkpoint function.

Pch2 can both activate or silence the checkpoint, analogous to Pch2/TRIP13-Mad2 module in the mitotic spindle assembly checkpoint that monitors chromosome segregation. 

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