Publications of Peng Wu

Jiang, M.; Giannino, N.; Goebel, G. L.; Sievers, S.; Wu, P.: LIN28-Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs. ChemMedChem (2024)

Goebel, G. L.; Giannino, N.; Lampe, P.; Qiu, X.; Schloßhauer, J.; Imig, J.; Sievers, S.; Wu, P.: Profiling Cellular Morphological Changes Induced by Dual-targeting PROTACs of Aurora Kinase and RNA-binding Protein YTHDF2. ChemBioChem: A European Journal of Chemical Biology (2024)

Liu, Y.; Goebel, G. L.; Kanis, L.; Hastürk, O.; Kemker, K.; Wu, P.: Aminothiazolone Inhibitors Disrupt the Protein–RNA Interaction of METTL16 and Modulate the m6A RNA Modification. JACS Au (2024)

Borgelt, L.; Hohnen, L.; Hommen, P.; Goebel , G. L.; Liu, Y.; O'Mahony, G.; Wu, P.: N-Biphenyl Pyrrolinones and Dibenzofurans as RNA-Binding Protein LIN28 Inhibitors Disrupting the LIN28–Let-7 Interaction. ACS Medicinal Chemistry Letters (2023)

Borgelt, L.; Haacke, N.; Lampe, P.; Qiu, X.; Gasper, R.; Schiller, D.; Sievers, S.; Wu, P.: Small-molecule screening of ribonuclease L binders for RNA degradation. Biomedicine & Pharmacotherapy 154 (2023)

Borgelt, L.; Wu, P.: Targeting Ribonucleases with Small Molecules and Bifunctional Molecules. ACS Chemical Biology 18 (10), pp. 2101 - 2113 (2023)

Hommen, P.; Hwang, J.; Huang, F.; Hohnen, L.; Wu, P.: Chromenopyrazole−Peptide Conjugates as Small-Molecule Based Inhibitors Disrupting the Protein−RNA Interaction of LIN28-let-7. ChemBioChem: A European Journal of Chemical Biology (2023)

Hwang, J.; Haacke, N.; Borgelt, L.; Qiu, X.; Gasper, R.; Wu, P.: Rational design and evaluation of 2-((pyrrol-2-yl)methylene)thiophen-4-ones as RNase L inhibitors. European Journal of Medicinal Chemistry (2023)

Borgelt, L.; Huang, F.; Hohnen, L.; Qiu, X.; Goebel, G. L.; Hommen, P.; Wu, P.: Spirocyclic Chromenopyrazole Inhibitors Disrupting the Interaction between the RNA-Binding Protein LIN28 and Let-7. ChemBioChem: A European Journal of Chemical Biology (2023)

Avathan Veettil, A.; Kirchhoff, J.-L.; Brieger, L.; Strohmann, C.; Wu, P.: Petasis Sequence Reactions for the Scaffold-Diverse Synthesis of Bioactive Polycyclic Small Molecules. ACS Omega 8 (1), pp. 1168 - 1181 (2023)

Wu, P.; Goebel, G. L.; Qiu, X.: Kinase-targeting small-molecule inhibitors and emerging bifunctional molecules. Trends in Pharmacological Sciences (2022)

Hui, C.; Liu, Y.; Jiang, M.; Wu, P.: Cyclobutane-containing scaffolds in bioactive small molecules. Trends in Chemistry (2022)

Hwang, J.; Qiu, X.; Borgelt, L.; Haacke, N.; Kanis, L.; Petroulia, S.; Gasper, R.; Schiller, D.; Lampe, P.; Sievers, S. et al.; Imig, J.; Wu, P.: Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents. Bioorganic & Medicinal Chemistry 58, 116653, pp. 1 - 15 (2022)

Goebel, G. L.; Hohnen, L.; Borgelt, L.; Hommen, P.; Qiu, X.; Lightfoot , H.; Wu, P.: Small molecules with tetrahydroquinoline-containing Povarov scaffolds as inhibitors disrupting the ProteineRNA interaction of LIN28elet-7. European Journal of Medicinal Chemistry 228, 114014, pp. 1 - 14 (2021)

Borgelt, L.; Li, F.; Hommen, P.; Lampe, P.; Hwang, J.; Goebel, G. L.; Sievers, S.; Wu, P.: Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein-RNA Interaction of LIN28 and Let-7. ACS Medicinal Chemistry Letters 12 (6), pp. 893 - 898 (2021)

Hwang, J.; Borgelt, L.; Wu, P.: Multicomponent Petasis Reaction for the Synthesis of Functionalized 2-Aminothiophenes and Thienodiazepines. ACS Combinatorial Science 22 (10), pp. 495 - 499 (2020)

Wu, P.: Inhibition of RNA-binding proteins with small molecules. Nature Reviews Chemistry 4, pp. 441 - 458 (2020)

Wu, P.; Manna, D.: Optochemical Control of Protein Degradation. Chembiochem 21 (16), pp. 2250 - 2252 (2020)

Wu, P.; Givskov, M.; Nielsen, T. E.: Reactivity and Synthetic Applications of Multicomponent Petasis Reactions. Chemical Reviews, pp. 1 - 46 (2019)