Publications of Sonja Sievers

Hoock, J. G.; Burhop, A.; Greiner, L. C.; Schölermann, B.; Da Cruz Lopes Guita, C.; Liu, J.; Bag, S.; Pahl, A.; Sievers, S.; Scheel, R. et al.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products. ChemBioChem: A European Journal of Chemical Biology (2025)

Griggs, S. D.; Piticari, A.-S.; Liver, S.; Arter, C.; Sievers, S.; Marsden, S. P.; Nelson, A.: Phenotype-directed discovery of diverse, biologically-relevant molecular scaffolds. Chemical Communications (2025)

Schulz, T.; Gontla, R.; Teuber, A.; Beerbaum, M.; Fletcher, B.; Mühlenberg, T.; Kaitsiotou, H.; Jardick, J.; Jeyakumar, K.; Keul, M. et al.; Müller, M.; Sievers, S.; Bauer, S.; Rauh, D.: Design, Synthesis, and SAR of Covalent KIT and PDGFRA Inhibitors─Exploring Their Potential in Targeting GIST. Journal of Medicinal Chemistry (2025)

Bauer, L. G.; Ward, J. A.; Díaz-Sáez , L.; Sundström, Y.; Tolvanen, T.; Alarcón Barrera, J. C.; Kostidis, S.; Rogers, C. M.; Panagakou, I.; Singh, U. et al.; Rothweiler, E. M.; Gonzalez Orta, A.; Kaniskan, H. Ü.; Hu, J.; Sievers, S.; Waldmann, H.; Giera, M.; Sundström, M.; Berg, L.; Huber, K.: Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors. Angewandte Chemie, International Edition in English (2024)

Jiang, M.; Giannino, N.; Goebel, G. L.; Sievers, S.; Wu, P.: LIN28-Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs. ChemMedChem (2024)

Rezaei Adariani, S.; Agne, D.; Koska, S.; Burhop, A.; Seitz, C.; Warmers, J.; Janning, P.; Metz, M.; Pahl, A.; Sievers, S. et al.; Waldmann, H.; Ziegler, S.: Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay. Journal of Medicinal Chemistry (2024)

Cigler, M.; Imrichova, H.; Frommelt, F.; Caramelle, L.; Depta, L.; Rukavina, A.; Kagiou, C.; Hannich, T.; Mayor-Ruiz, C.; Superti-Furga, G. et al.; Sievers, S.; Forrester, A.; Laraia, L.; Waldmann, H.; Winter, G.: Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. Nature Chemical Biology (2024)

Goebel, G. L.; Giannino, N.; Lampe, P.; Qiu, X.; Schloßhauer, J.; Imig, J.; Sievers, S.; Wu, P.: Profiling Cellular Morphological Changes Induced by Dual-targeting PROTACs of Aurora Kinase and RNA-binding Protein YTHDF2. ChemBioChem: A European Journal of Chemical Biology (2024)

Patil, S.; Cremosnik, G. S.; Dötsch, L.; Flegel, J.; Schulte, B.; Maier, K. C.; Zumer, K.; Cramer, P.; Janning, P.; Sievers, S. et al.; Waldmann, H.: Tafbromin selectively targets the TAF1 bromodomain. Angewandte Chemie, International Edition in English (2024)

Pahl, A.; Liu, J.; Patil, S.; Rezaei Adariani, S.; Schölermann, B.; Warmers, J.; Bonowski, J.; Koska, S.; Akbulut, Y.; Seitz, C. et al.; Sievers, S.; Ziegler, S.; Waldmann, H.: Illuminating Dark Chemical Matter Using the Cell Painting Assay. Journal of Medicinal Chemistry (2024)

Wang, L.; Yilmaz, F.; Yildirim, O.; Schölermann, B.; Bag, S.; Greiner, L.; Pahl, A.; Sievers, S.; Scheel, R.; Strohmann, C. et al.; Squire, C.; Foley, D. J.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Discovery of a Novel Pseudo-Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling. Advanced Science (2024)

Dötsch, L.; Davies, C.; Hennes, E.; Schönfeld, J.; Kumar, A.; Da Cruz Lopes Guita, C.; Ehrler, J. H.; Hiesinger, K.; Thavam, S.; Janning, P. et al.; Sievers, S.; Knapp, S.; Proschak, E.; Ziegler, S.; Waldmann, H.: Discovery of the sEH Inhibitor Epoxykynin as a Potent Kynurenine Pathway Modulator. Journal of Medicinal Chemistry (2024)

Bag, S.; Liu, J.; Patil, S.; Bonowski, J.; Schölermann, B.; Zhang, R.; Wang , L.; Pahl, A.; Sievers, S.; Brieger, L. et al.; Strohmann, C.; Grigalunas, M.; Waldmann, H.: A divergent intermediate strategy yields biologically diverse pseudo-natural products. Nature Chemistry (2024)

Corkery, D.; Ursu, A.; Lucas, B.; Grigalunas, M.; Kriegler, S.; Oliva, R.; Dec, R.; Koska, S.; Pahl, A.; Sievers, S. et al.; Ziegler, S.; Winter, R.; Wu, Y.; Waldmann, H.: Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair. ChemBioChem: A European Journal of Chemical Biology (2023)

Xie, J.; Pahl, A.; Krzyzanowski, A.; Krupp, A.; Liu, J.; Koska, S.; Schölermann, B.; Zhang, R.; Bonowski, J.; Sievers, S. et al.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space. Angewandte Chemie, International Edition in English (2023)

Borgelt, L.; Haacke, N.; Lampe, P.; Qiu, X.; Gasper, R.; Schiller, D.; Sievers, S.; Wu, P.: Small-molecule screening of ribonuclease L binders for RNA degradation. Biomedicine & Pharmacotherapy 154 (2023)

Pahl, A.; Schölermann, B.; Lampe, P.; Rusch, M.; Dow, M.; Hedberg, C.; Nelson, A.; Sievers, S.; Waldmann, H.; Ziegler, S.: Morphological subprofile analysis for bioactivity annotation of small molecules. Cell Chemical Biology (2023)

Tong , Y.; Lee, Y.; Liu, X.; Childs-Diney, J. L.; Suresh , B. M.; Benhamou, R.; Yang, C.; Li, W.; Costales, M. G.; Haniff, H. S. et al.; Sievers, S.; Abegg, D.; Wegner, T.; Paulisch, T. O.; Lekah, E.; Grefe, M.; Crynen , G.; Van Meter, M.; Wang, T.; Gibaut, Q. M. R.; Cleveland, J. L.; Adibekian, A.; Glorius, F.; Waldmann, H.; Disney, M. D.: Programming inactive RNA-binding small molecules into bioactive degraders. Nature (2023)

Pkolo, E. A.; Pahl, A.; Sievers, S.; Nelson, A.; Marsden, S.: Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3-Rich Compounds With Distinct Phenotypic Effects. Chemistry – A European Journal (2023)

Withmarsh-Everiss, T.; Wang, Z.; Hauberg Hansen, C.; Depta, L.; Sassetti, E.; Dan, O. R.; Pahl, A.; Sievers, S.; Laraia, L.: Identification of biologically diverse tetrahydronaphtalen-2-ols through the synthesis and phenotypic profiling of chemically diverse, estradiol-inspired compounds. ChemBioChem: A European Journal of Chemical Biology (2023)