Publications of Michael Grigalunas

Hoock, J. G.; Burhop, A.; Greiner, L. C.; Schölermann, B.; Da Cruz Lopes Guita, C.; Liu, J.; Bag, S.; Pahl, A.; Sievers, S.; Scheel, R. et al.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: An Indole Dearomatization Strategy for the Synthesis of Pseudo-Natural Products. ChemBioChem: A European Journal of Chemical Biology (2025)

Cheng, X.-F.; Grigalunas, M.; Waldmann, H.: Progress and opportunities of pseudo-natural-product design in molecular discovery. ARKIVOC (2024)

Wang, L.; Yilmaz, F.; Yildirim, O.; Schölermann, B.; Bag, S.; Greiner, L.; Pahl, A.; Sievers, S.; Scheel, R.; Strohmann, C. et al.; Squire, C.; Foley, D. J.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Discovery of a Novel Pseudo-Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling. Advanced Science (2024)

Bag, S.; Liu, J.; Patil, S.; Bonowski, J.; Schölermann, B.; Zhang, R.; Wang , L.; Pahl, A.; Sievers, S.; Brieger, L. et al.; Strohmann, C.; Grigalunas, M.; Waldmann, H.: A divergent intermediate strategy yields biologically diverse pseudo-natural products. Nature Chemistry (2024)

Corkery, D.; Ursu, A.; Lucas, B.; Grigalunas, M.; Kriegler, S.; Oliva, R.; Dec, R.; Koska, S.; Pahl, A.; Sievers, S. et al.; Ziegler, S.; Winter, R.; Wu, Y.; Waldmann, H.: Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair. ChemBioChem: A European Journal of Chemical Biology (2023)

Xie, J.; Pahl, A.; Krzyzanowski, A.; Krupp, A.; Liu, J.; Koska, S.; Schölermann, B.; Zhang, R.; Bonowski, J.; Sievers, S. et al.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space. Angewandte Chemie, International Edition in English (2023)

Aoyama, H.; Davies, C.; Liu, J.; Pahl, A.; Kirchhoff, J.-L.; Scheel, R.; Strohman, C.; Grigalunas, M.; Waldmann, H.: Collective Synthesis of Sarpagine and Macroline Alkaloid-Inspired Compounds. Chemistry – A European Journal (2023)

Krzyzanowski, A.; Pahl, A.; Grigalunas, M.; Waldmann, H.: Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity. Journal of Medicinal Chemistry (2023)

Liu, J.; Zhang, R.; Mallick, S.; Wientjens, C.; Flegel, J.; Krupp, A.; Strohmann, C.; Grassing, C.; Merten, C.; Pahl, A. et al.; Grigalunas, M.; Waldmann, H.: A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway. Chemical Science 14 (2023)

Young, R.; Flitsch, S.; Grigalunas, M.; Leeson, P.; Quinn, R.; Turner, N.; Waldmann, H.: The Time and Place for Nature in Drug Discovery. Journal of the American Chemical Society 2 (11) (2022)

Schölermann, B.; Bonowski, J.; Grigalunas, M.; Burhop, A.; Xie, Y.; Hook, J.; Liu, J.; Nelson, A.; Dow, M.; Nowak, C. et al.; Pahl, A.; Sievers, S.; Ziegler, S.: Identification of Dihydroorotate Dehydrogenase Inhibitors using the Cell Painting Assay. ChemBioChem: A European Journal of Chemical Biology (2022)

Grigalunas, M.; Patil, S.; Krzyzanowski, A.; Pahl, A.; Flegel, J.; Schölermann, B.; Xie, J.; Sievers, S.; Ziegler, S.; Waldmann, H.: Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone. Chemistry – A European Journal (2022)

Grigalunas, M.; Brakmann, S.; Waldmann, H.: Chemical Evolution of Natural Product Structure. Journal of the American Chemical Society 144 (8), pp. 3314 - 3329 (2022)

Akbarzadeh, M.; Flegel, J.; Patil, S.; Shang, E.; Narayan, R.; Buchholzer, M.; Jasemi, N. S. K.; Grigalunas, M.; Krzyzanowski, A.; Abegg, D. et al.; Shuster, A.; Potowski, M.; Karatas, H.; Karageorgis, G.; Mosaddeghzadeh, N.; Zischinsky, M.-L.; Merten, C.; Golz, C.; Brieger, L.; Strohmann, C.; Antonchick, A. P.; Janning, P.; Adibekian, A.; Goody, R. S.; Ahmadian, M. R.; Ziegler, S.; Waldmann, H.: The Pseudo-Natural Product Rhonin Targets RHOGDI. Angewandte Chemie International Edition, pp. 1 - 27 (2022)

Akbarzadeh, M.; Flegel, J.; Patil, S.; Shang, E.; Narayan, R.; Buchholzer, M.; Jasemi, N. S. K.; Grigalunas, M.; Krzyzanowski, A.; Abegg, D. et al.; Shuster, A.; Potowski, M.; Karatas, H.; Karageorgis, G.; Mosaddeghzadeh, N.; Zischinsky, M.-L.; Merten, C.; Golz, C.; Brieger, L.; Strohmann, C.; Antonchick, A. P.; Janning, P.; Adibekian, A.; Goody, R. S.; Ahmadian, M. R.; Ziegler, S.; Waldmann, H.: The Pseudo-Natural Product Rhonin Targets RHOGDI. Angewandte Chemie, pp. 1 - 27 (2022)

Burhop, A.; Bag, S.; Grigalunas, M.; Woitalla, S.; Bodenbinder, P.-J.; Brieger, L.; Strohmann, C.; Pahl, A.; Sievers, S.; Waldmann, H.: Synthesis of Indofulvin Pseudo-Natural Products Yields a New Autophagy Inhibitor Chemotype. Advanced Science 8 (19), e2102042, pp. 1 - 10 (2021)

Yildirim, O.; Grigalunas, M.; Brieger, L.; Strohmann, C.; Antonchick, A. P.; Waldmann, H.: Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions. Angewandte Chemie International Edition 60 (36), pp. 20012 - 20020 (2021)

Yildirim, O.; Grigalunas, M.; Brieger, L.; Strohmann, C.; Antonchick, A. P.; Waldmann, H.: Dynamic Catalytic Highly Enantioselective 1,3-Dipolar Cycloadditions. Angewandte Chemie 133 (36), pp. 20165 - 20173 (2021)

Grigalunas, M.; Burhop, A.; Zinken, S.; Pahl, A.; Gally, J.-M.; Wild, N.; Mantel, Y.; Sievers, S.; Foley, D. J.; Scheel, R. et al.; Strohmann, C.; Antonchick, A. P.; Waldmann, H.: Natural product fragment combination to performance-diverse pseudo-natural products. Nature Communications 12 (1), 1883, pp. 1 - 11 (2021)

Grigalunas, M.; Burhop, A.; Christoforow, A.; Waldmann, H.: Pseudo-natural products and natural product-inspired methods in chemical biology and drug discovery. Current Opinion in Chemical Biology 56, pp. 111 - 118 (2020)