Publications of Jana Flegel

Patil, S.; Cremosnik, G. S.; Dötsch, L.; Flegel, J.; Schulte, B.; Maier, K. C.; Zumer, K.; Cramer, P.; Janning, P.; Sievers, S. et al.; Waldmann, H.: Tafbromin selectively targets the TAF1 bromodomain. Angewandte Chemie, International Edition in English (2024)

Liu, J.; Zhang, R.; Mallick, S.; Wientjens, C.; Flegel, J.; Krupp, A.; Strohmann, C.; Grassing, C.; Merten, C.; Pahl, A. et al.; Grigalunas, M.; Waldmann, H.: A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway. Chemical Science 14 (2023)

Flegel, J.; Shaaban, S.; Jia, Z.-J.; Schulte, B.; Lian, Y.; Krzyzanowski, A.; Metz, M.; Schneidewind, T.; Wesseler , F.; Flegel, A. et al.; Reich, A.; Brause, A.; Xue, G.; Zhang, M.; Dötsch, L.; Stender, I. D.; Hoffmann, J.-E.; Scheel, R.; Janning, P.; Rastinejad, F.; Schade, D.; Strohmann, C.; Antonchick, A. P.; Sievers, S.; Alves, P.; Ziegler, S.; Waldmann, H.: The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. European Journal of Medicinal Chemistry (2022)

Wesseler, F.; Lohmann, S.; Riege, D.; Halver, J.; Roth, A.; Picholo, C.; Weber, S.; Takamiya, M.; Müller, E.; Ketzel, J. et al.; Flegel, J.; Gihring, A.; Rastegar, S.; Bertrand, J.; Baumann, U.; Knippschild, U.; Pfeifer, C.; Sievers, S.; Waldmann, H.; Schade, D.: Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. Journal of Medicinal Chemistry (2022)

Grigalunas, M.; Patil, S.; Krzyzanowski, A.; Pahl, A.; Flegel, J.; Schölermann, B.; Xie, J.; Sievers, S.; Ziegler, S.; Waldmann, H.: Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone. Chemistry – A European Journal (2022)

Akbarzadeh, M.; Flegel, J.; Patil, S.; Shang, E.; Narayan, R.; Buchholzer, M.; Jasemi, N. S. K.; Grigalunas, M.; Krzyzanowski, A.; Abegg, D. et al.; Shuster, A.; Potowski, M.; Karatas, H.; Karageorgis, G.; Mosaddeghzadeh, N.; Zischinsky, M.-L.; Merten, C.; Golz, C.; Brieger, L.; Strohmann, C.; Antonchick, A. P.; Janning, P.; Adibekian, A.; Goody, R. S.; Ahmadian, M. R.; Ziegler, S.; Waldmann, H.: The Pseudo-Natural Product Rhonin Targets RHOGDI. Angewandte Chemie International Edition, pp. 1 - 27 (2022)

Akbarzadeh, M.; Flegel, J.; Patil, S.; Shang, E.; Narayan, R.; Buchholzer, M.; Jasemi, N. S. K.; Grigalunas, M.; Krzyzanowski, A.; Abegg, D. et al.; Shuster, A.; Potowski, M.; Karatas, H.; Karageorgis, G.; Mosaddeghzadeh, N.; Zischinsky, M.-L.; Merten, C.; Golz, C.; Brieger, L.; Strohmann, C.; Antonchick, A. P.; Janning, P.; Adibekian, A.; Goody, R. S.; Ahmadian, M. R.; Ziegler, S.; Waldmann, H.: The Pseudo-Natural Product Rhonin Targets RHOGDI. Angewandte Chemie, pp. 1 - 27 (2022)

Liu, J.; Flegel, J.; Otte, F.; Pahl, A.; Sievers, S.; Strohmann, C.; Waldmann, H.: Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids. Angewandte Chemie International Edition 60 (39), pp. 21384 - 21395 (2021)

Liu, J.; Flegel, J.; Otte, F.; Pahl, A.; Sievers, S.; Strohmann, C.; Waldmann, H.: Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids. Angewandte Chemie 133 (39), pp. 21554 - 21565 (2021)

Rehan, M.; Flegel, J.; Heitkamp, F.; Pergomet, J. L.; Otte, F.; Strohmann, C.; Kumar, K.: Asymmetric Synthesis of 3,3 '-Piperidinoyl Spirooxindoles and Discovery of Stereospecific Cycloadducts as Novel Hedgehog Pathway Modulators. Synthesis 52 (21), pp. 3140 - 3152 (2020)

Shaaban, S.; Davies, C.; Merten, C.; Flegel, J.; Otte, F.; Strohmann, C.; Waldmann, H.: Rh(III)-catalyzed C-H Activation of Aryl-Hydroxamates for the Synthesis of Isoindolinones. Chemistry – A European Journal 26 (47), pp. 10729 - 10734 (2020)

Kremer, L.; Hennes, E.; Brause, A.; Ursu, A.; Robke, L.; Matsubayashi, H. T.; Nihongaki, Y.; Flegel, J.; Mejdrová, I.; Eickhoff, J. et al.; Baumann, M.; Nencka, R.; Janning, P.; Kordes, S.; Schöler, H. R.; Sterneckert, J.; Inoue, T.; Ziegler, S.; Waldmann, H.: Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angewandte Chemie, International Edition, pp. 1 - 37 (2019)

Kremer, L.; Hennes, E.; Brause, A.; Ursu, A.; Robke, L.; Matsubayashi , H. T.; Nihongaki, Y.; Flegel, J.; Mejdrová, I.; Eickhoff, J. et al.; Baumann, M.; Nencka, R.; Janning, P.; Kordes, S.; Schöler, H. R.; Sterneckert, J.; Inoue, T.; Ziegler, S.; Waldmann, H.: Discovery of the Hedgehog Pathway Inhibitor Pipinib that Targets PI4KIIIß. Angewandte Chemie, pp. 1 - 37 (2019)

Nemec, V.; Hylsová, M.; Maier, L.; Flegel, J.; Sievers, S.; Ziegler, S.; Schröder, M.; Berger, B.-T.; Chaikuad, A.; Valcíková, B. et al.; Uldrijan, S.; Drápela, S.; Soucek, K.; Waldmann, H.; Knapp, S.; Paruch, K.: Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angewandte Chemie International Edition 58 (4), pp. 1062 - 1066 (2019)

Nemec, V.; Hylsová, M.; Maier, L.; Flegel, J.; Sievers, S.; Ziegler, S.; Schröder, M.; Berger, B.-T.; Chaikuad, A.; Valcíková, B. et al.; Uldrijan, S.; Drápela, S.; Soucek, K.; Waldmann, H.; Knapp, S.; Paruch, K.: Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway. Angewandte Chemie 131 (4), pp. 1074 - 1078 (2019)

Li, H.; Gontla, R.; Flegel, J.; Merten , C.; Ziegler, S.; Antonchick, A. P.; Waldmann, H.: Enantioselective Formal C(sp3 )-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives. Angewandte Chemie International Edition 58 (1), pp. 307 - 311 (2018)

Xin, X.; Zimmermann, S.; Flegel, J.; Otte, F.; Knauer, L.; Strohmann, C.; Ziegler, S.; Kumar, K.: Unravelling Synthesis and Chemistry of Stable, Acyclic and Double-Deficient 1,3-Butadienes: An endo-selective Diels-Alder Route to Hedgehog Pathway Inhibitors. Chemistry – A European Journal 25 (11), pp. 2717 - 2722 (2018)

Shan, G.; Flegel, J.; Li, H.; Merten, C.; Ziegler, S.; Antonchick, A. P.; Waldmann, H.: C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors. Angewandte Chemie International Edition 57 (43), pp. 14250 - 14254 (2018)

Shan, G.; Flegel, J.; Li, H.; Merten, C.; Ziegler, S.; Antonchick, A. P.; Waldmann, H.: C-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors. Angewandte Chemie 130 (43), pp. 14446 - 14450 (2018)

Li, H.; Gontla, R.; Flegel, J.; Merten, C.; Ziegler, S.; Antonchick, A. P.; Waldmann, H.: Enantioselective Formal C(sp3 )-H Bond Activation in the Synthesis of Bioactive Spiropyrazolone Derivatives. Angewandte Chemie 131 (1), pp. 313 - 317 (2018)