Publications of Axel Pahl

Heinzke, A. L.; Zdrazil, B.; Leeson, P. D.; Young, R. J.; Pahl, A.; Waldmann, H.; Leach, A. R.: A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds. Scientific Data (2024)

Rezaei Adariani, S.; Agne, D.; Koska, S.; Burhop, A.; Seitz, C.; Warmers, J.; Janning, P.; Metz, M.; Pahl, A.; Sievers, S. et al.; Waldmann, H.; Ziegler, S.: Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay. Journal of Medicinal Chemistry (2024)

Heinzke, A. L.; Pahl, A.; Zdrazil, B.; Leach, A. R.; Waldmann, H.; Young, R. J.; Leeson, P. D.: Occurrence of "Natural Selection" in Successful Small Molecule Drug Discovery. Journal of Medicinal Chemistry 67 (13), pp. 11226 - 11241 (2024)

Pahl, A.; Grygorenko, O. O.; Konratov, I. O.; Waldmann, H.: Identification of readily available pseudo-natural products. RSC Medicinal Chemistry (2024)

Tandon, A.; Santura, A.; Waldmann, H.; Pahl, A.; Czodrowski, P.: Identification of lysosomotropism using explainable machine learning and morphological profiling cell painting data. RSC Medicinal Chemistry (2024)

Pahl, A.; Liu, J.; Patil, S.; Rezaei Adariani, S.; Schölermann, B.; Warmers, J.; Bonowski, J.; Koska, S.; Akbulut, Y.; Seitz, C. et al.; Sievers, S.; Ziegler, S.; Waldmann, H.: Illuminating Dark Chemical Matter Using the Cell Painting Assay. Journal of Medicinal Chemistry (2024)

Wang, L.; Yilmaz, F.; Yildirim, O.; Schölermann, B.; Bag, S.; Greiner, L.; Pahl, A.; Sievers, S.; Scheel, R.; Strohmann, C. et al.; Squire, C.; Foley, D. J.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Discovery of a Novel Pseudo-Natural Product Aurora Kinase Inhibitor Chemotype through Morphological Profiling. Advanced Science (2024)

Bag, S.; Liu, J.; Patil, S.; Bonowski, J.; Schölermann, B.; Zhang, R.; Wang , L.; Pahl, A.; Sievers, S.; Brieger, L. et al.; Strohmann, C.; Grigalunas, M.; Waldmann, H.: A divergent intermediate strategy yields biologically diverse pseudo-natural products. Nature Chemistry (2024)

Corkery, D.; Ursu, A.; Lucas, B.; Grigalunas, M.; Kriegler, S.; Oliva, R.; Dec, R.; Koska, S.; Pahl, A.; Sievers, S. et al.; Ziegler, S.; Winter, R.; Wu, Y.; Waldmann, H.: Inducin Triggers LC3-Lipidation and ESCRT-Mediated Lysosomal Membrane Repair. ChemBioChem: A European Journal of Chemical Biology (2023)

Xie, J.; Pahl, A.; Krzyzanowski, A.; Krupp, A.; Liu, J.; Koska, S.; Schölermann, B.; Zhang, R.; Bonowski, J.; Sievers, S. et al.; Strohmann, C.; Ziegler, S.; Grigalunas, M.; Waldmann, H.: Synthetic Matching of Complex Monoterpene Indole Alkaloid Chemical Space. Angewandte Chemie, International Edition in English (2023)

Krzyzanowski, A.; Pahl, A.; Grigalunas, M.; Waldmann, H.: Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity. Journal of Medicinal Chemistry (2023)

Liu, J.; Zhang, R.; Mallick, S.; Wientjens, C.; Flegel, J.; Krupp, A.; Strohmann, C.; Grassing, C.; Merten, C.; Pahl, A. et al.; Grigalunas, M.; Waldmann, H.: A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway. Chemical Science 14 (2023)

Pahl, A.; Schölermann, B.; Lampe, P.; Rusch, M.; Dow, M.; Hedberg, C.; Nelson, A.; Sievers, S.; Waldmann, H.; Ziegler, S.: Morphological subprofile analysis for bioactivity annotation of small molecules. Cell Chemical Biology (2023)

Liu, J.; Malick, S.; Grassin, C.; Lucas, B.; Schölermann, B.; Pahl, A.; Scheel, R.; Strohmann Carsten; Protzel, C.; Berg, T. et al.; Merten, C.; Waldmann, H.: Morphological profiling identifies the motor protein Eg5 as cellular target of spirooxindoles. Angewandte Chemie, International Edition in English (2023)

Pkolo, E. A.; Pahl, A.; Sievers, S.; Nelson, A.; Marsden, S.: Scaffold Remodelling of Diazaspirotricycles Enables Synthesis of Diverse sp3-Rich Compounds With Distinct Phenotypic Effects. Chemistry – A European Journal (2023)

Withmarsh-Everiss, T.; Wang, Z.; Hauberg Hansen, C.; Depta, L.; Sassetti, E.; Dan, O. R.; Pahl, A.; Sievers, S.; Laraia, L.: Identification of biologically diverse tetrahydronaphtalen-2-ols through the synthesis and phenotypic profiling of chemically diverse, estradiol-inspired compounds. ChemBioChem: A European Journal of Chemical Biology (2023)

Schölermann, B.; Bonowski, J.; Grigalunas, M.; Burhop, A.; Xie, Y.; Hook, J.; Liu, J.; Nelson, A.; Dow, M.; Nowak, C. et al.; Pahl, A.; Sievers, S.; Ziegler, S.: Identification of Dihydroorotate Dehydrogenase Inhibitors using the Cell Painting Assay. ChemBioChem: A European Journal of Chemical Biology (2022)

Grigalunas, M.; Patil, S.; Krzyzanowski, A.; Pahl, A.; Flegel, J.; Schölermann, B.; Xie, J.; Sievers, S.; Ziegler, S.; Waldmann, H.: Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone. Chemistry – A European Journal (2022)

Akbarzadeh, M.; Deipenwisch, I.; Schoelermann, B.; Pahl, A.; Sievers, S.; Ziegler, S.; Waldmann, H.: Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology, pp. 1053 - 1064 (2022)

Akbarzadeh, M.; Deipenwisch, I.; Schoelermann, B.; Pahl, A.; Sievers, S.; Ziegler, S.; Waldmann, H.: Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology, pp. 1 - 16 (2021)