Publications of Herbert Waldmann

Aoyama, H.; Davies, C.; Liu, J.; Pahl, A.; Kirchhoff, J.-L.; Scheel, R.; Strohman, C.; Grigalunas, M.; Waldmann, H.: Collective Synthesis of Sarpagine and Macroline Alkaloid-Inspired Compounds. Chemistry – A European Journal (2023)

Krzyzanowski, A.; Pahl, A.; Grigalunas, M.; Waldmann, H.: Spacial Score─A Comprehensive Topological Indicator for Small-Molecule Complexity. Journal of Medicinal Chemistry (2023)

Liu, J.; Zhang, R.; Mallick, S.; Wientjens, C.; Flegel, J.; Krupp, A.; Strohmann, C.; Grassing, C.; Merten, C.; Pahl, A. et al.; Grigalunas, M.; Waldmann, H.: A highly enantioselective intramolecular 1,3-dipolar cycloaddition yields novel pseudo-natural product inhibitors of the Hedgehog signalling pathway. Chemical Science 14 (2023)

Pahl, A.; Schölermann, B.; Lampe, P.; Rusch, M.; Dow, M.; Hedberg, C.; Nelson, A.; Sievers, S.; Waldmann, H.; Ziegler, S.: Morphological subprofile analysis for bioactivity annotation of small molecules. Cell Chemical Biology (2023)

Tong , Y.; Lee, Y.; Liu, X.; Childs-Diney, J. L.; Suresh , B. M.; Benhamou, R.; Yang, C.; Li, W.; Costales, M. G.; Haniff, H. S. et al.; Sievers, S.; Abegg, D.; Wegner, T.; Paulisch, T. O.; Lekah, E.; Grefe, M.; Crynen , G.; Van Meter, M.; Wang, T.; Gibaut, Q. M. R.; Cleveland, J. L.; Adibekian, A.; Glorius, F.; Waldmann, H.; Disney, M. D.: Programming inactive RNA-binding small molecules into bioactive degraders. Nature (2023)

Liu, J.; Malick, S.; Grassin, C.; Lucas, B.; Schölermann, B.; Pahl, A.; Scheel, R.; Strohmann Carsten; Protzel, C.; Berg, T. et al.; Merten, C.; Waldmann, H.: Morphological profiling identifies the motor protein Eg5 as cellular target of spirooxindoles. Angewandte Chemie, International Edition in English (2023)

Flegel, J.; Shaaban, S.; Jia, Z.-J.; Schulte, B.; Lian, Y.; Krzyzanowski, A.; Metz, M.; Schneidewind, T.; Wesseler , F.; Flegel, A. et al.; Reich, A.; Brause, A.; Xue, G.; Zhang, M.; Dötsch, L.; Stender, I. D.; Hoffmann, J.-E.; Scheel, R.; Janning, P.; Rastinejad, F.; Schade, D.; Strohmann, C.; Antonchick, A. P.; Sievers, S.; Alves, P.; Ziegler, S.; Waldmann, H.: The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. European Journal of Medicinal Chemistry (2022)

Krzyzanowski, A.; Esser, L. M.; Willaume, A.; Prudent, R.; `T Hart, P.; Waldmann, H.: Development of Macrocyclic PRMT5-Adaptor Protein Interaction Inhibitors. European Journal of Medicinal Chemistry (2022)

Wesseler, F.; Lohmann, S.; Riege, D.; Halver, J.; Roth, A.; Picholo, C.; Weber, S.; Takamiya, M.; Müller, E.; Ketzel, J. et al.; Flegel, J.; Gihring, A.; Rastegar, S.; Bertrand, J.; Baumann, U.; Knippschild, U.; Pfeifer, C.; Sievers, S.; Waldmann, H.; Schade, D.: Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. Journal of Medicinal Chemistry (2022)

Picard, L. K.; Littwitz-Salomon, E.; Waldmann, H.; Watzl, C.: Inhibition of Glucose Uptake Blocks Proliferation but Not Cytotoxic Activity of NK Cells. Cells 11 (21) (2022)

Young, R.; Flitsch, S.; Grigalunas, M.; Leeson, P.; Quinn, R.; Turner, N.; Waldmann, H.: The Time and Place for Nature in Drug Discovery. Journal of the American Chemical Society 2 (11) (2022)

Grigalunas, M.; Patil, S.; Krzyzanowski, A.; Pahl, A.; Flegel, J.; Schölermann, B.; Xie, J.; Sievers, S.; Ziegler, S.; Waldmann, H.: Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone. Chemistry – A European Journal (2022)

Davies, C.; Dötsch, L.; Ciulla, M. G.; Hennes, E.; Yoshida, K.; Gasper, R.; Scheel, R.; Sievers, S.; Strohmann, C.; Kumar, K. et al.; Ziegler, S.; Waldmann, H.: Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype. Angewandte Chemie, International Edition in English (2022)

Akbarzadeh, M.; Deipenwisch, I.; Schoelermann, B.; Pahl, A.; Sievers, S.; Ziegler, S.; Waldmann, H.: Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology, pp. 1053 - 1064 (2022)

Foley, D.; Waldmann, H.: Ketones as strategic building blocks for the synthesis of natural product-inspired compounds. Chemical Society Reviews 51 (10), pp. 4094 - 4120 (2022)

Jones, P.; Waldmann, H.: IMI European Lead Factory — democratizing access to highthroughput screening. Nature Reviews Drug Discovery 21, pp. 245 - 246 (2022)

Davies, C.; Shaaban, S.; Waldmann, H.: Asymmetric catalysis with chiral cyclopentadienyl complexes to access privileged scaffolds. Trends in Chemistry 4 (4), pp. 318 - 330 (2022)

Niggemeyer, G.; Knyazeva, A.; Gasper, R.; Corkery, D.; Bodenbinder, P.-J.; Holstein, J. J.; Sievers, S.; Wu, Y.-W.; Waldmann, H.: Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation. Angewandte Chemie International Edition 61 (11), pp. 1 - 21 (2022)

Niggemeyer, G.; Knyazeva, A.; Gasper, R.; Corkery, D.; Bodenbinder, P.-J.; Holstein, J. J.; Sievers, S.; Wu, Y.-W.; Waldmann, H.: Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation. Angewandte Chemie 134 (11), pp. 1 - 21 (2022)

Grigalunas, M.; Brakmann, S.; Waldmann, H.: Chemical Evolution of Natural Product Structure. Journal of the American Chemical Society 144 (8), pp. 3314 - 3329 (2022)