Publications of Sonja Sievers

Flegel, J.; Shaaban, S.; Jia, Z.-J.; Schulte, B.; Lian, Y.; Krzyzanowski, A.; Metz, M.; Schneidewind, T.; Wesseler , F.; Flegel, A. et al.; Reich, A.; Brause, A.; Xue, G.; Zhang, M.; Dötsch, L.; Stender, I. D.; Hoffmann, J.-E.; Scheel, R.; Janning, P.; Rastinejad, F.; Schade, D.; Strohmann, C.; Antonchick, A. P.; Sievers, S.; Alves, P.; Ziegler, S.; Waldmann, H.: The Highly Potent AhR Agonist Picoberin Modulates Hh-Dependent Osteoblast Differentiation. European Journal of Medicinal Chemistry (2022)

Wesseler, F.; Lohmann, S.; Riege, D.; Halver, J.; Roth, A.; Picholo, C.; Weber, S.; Takamiya, M.; Müller, E.; Ketzel, J. et al.; Flegel, J.; Gihring, A.; Rastegar, S.; Bertrand, J.; Baumann, U.; Knippschild, U.; Pfeifer, C.; Sievers, S.; Waldmann, H.; Schade, D.: Phenotypic Discovery of Triazolo[1,5-c]quinazolines as a First-In-Class Bone Morphogenetic Protein Amplifier Chemotype. Journal of Medicinal Chemistry (2022)

Schölermann, B.; Bonowski, J.; Grigalunas, M.; Burhop, A.; Xie, Y.; Hook, J.; Liu, J.; Nelson, A.; Dow, M.; Nowak, C. et al.; Pahl, A.; Sievers, S.; Ziegler, S.: Identification of Dihydroorotate Dehydrogenase Inhibitors using the Cell Painting Assay. ChemBioChem: A European Journal of Chemical Biology (2022)

Grigalunas, M.; Patil, S.; Krzyzanowski, A.; Pahl, A.; Flegel, J.; Schölermann, B.; Xie, J.; Sievers, S.; Ziegler, S.; Waldmann, H.: Unprecedented Combination of Polyketide Natural Product Fragments Identifies the New Hedgehog Signaling Pathway Inhibitor Grismonone. Chemistry – A European Journal (2022)

Davies, C.; Dötsch, L.; Ciulla, M. G.; Hennes, E.; Yoshida, K.; Gasper, R.; Scheel, R.; Sievers, S.; Strohmann, C.; Kumar, K. et al.; Ziegler, S.; Waldmann, H.: Identification of a Novel Pseudo-Natural Product Type IV IDO1 Inhibitor Chemotype. Angewandte Chemie, International Edition in English (2022)

Akbarzadeh, M.; Deipenwisch, I.; Schoelermann, B.; Pahl, A.; Sievers, S.; Ziegler, S.; Waldmann, H.: Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology, pp. 1053 - 1064 (2022)

Hwang, J.; Qiu, X.; Borgelt, L.; Haacke, N.; Kanis, L.; Petroulia, S.; Gasper, R.; Schiller, D.; Lampe, P.; Sievers, S. et al.; Imig, J.; Wu, P.: Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents. Bioorganic & Medicinal Chemistry 58, 116653, pp. 1 - 15 (2022)

Niggemeyer, G.; Knyazeva, A.; Gasper, R.; Corkery, D.; Bodenbinder, P.-J.; Holstein, J. J.; Sievers, S.; Wu, Y.-W.; Waldmann, H.: Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation. Angewandte Chemie International Edition 61 (11), pp. 1 - 21 (2022)

Niggemeyer, G.; Knyazeva, A.; Gasper, R.; Corkery, D.; Bodenbinder, P.-J.; Holstein, J. J.; Sievers, S.; Wu, Y.-W.; Waldmann, H.: Synthesis of 20-Membered Macrocyclic Pseudo-Natural Products Yields Inducers of LC3 Lipidation. Angewandte Chemie 134 (11), pp. 1 - 21 (2022)

Wesseler, F.; Riege, D.; Puthanveedu, M.; Halver, J.; Müller, E.; Bertrand, J.; Antonchick, A. P.; Sievers, S.; Waldmann, H.; Schade, D.: Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. Journal of Medicinal Chemistry, pp. 1 - 13 (2022)

Akbarzadeh, M.; Deipenwisch, I.; Schoelermann, B.; Pahl, A.; Sievers, S.; Ziegler, S.; Waldmann, H.: Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds. Cell Chemical Biology, pp. 1 - 16 (2021)

Schneidewind, T.; Brause, A.; Schölermann, B.; Sievers, S.; Pahl, A.; Sankar, M. G.; Winzker, M.; Janning, P.; Kumar, K.; Ziegler, S. et al.; Waldmann, H.: Combined morphological and proteome profiling reveals target-independent impairment of cholesterol homeostasis. Cell Chemical Biology 28 (12), pp. 1780 - 1794 (2021)

Heinrich, S.; Grote, M.; Sievers, S.; Kushnir, S.; Schulz, F.: Polyether Cyclization Cascade Alterations in Response to Monensin Polyketide Synthase Mutations. Chembiochem 23 (2), pp. 1 - 9 (2021)

Carrillo García, C.; Becker, C.; Forster, M.; Lohmann, S.; Freitag, P.; Laufer, S.; Sievers, S.; Fleischmann, B. K.; Hesse, M.; Schade, D.: High-Throughput Screening Platform in Postnatal Heart Cells and Chemical Probe Toolbox to Assess Cardiomyocyte Proliferation. Journal of Medicinal Chemistry 65 (2), pp. 1505 - 1524 (2021)

Burhop, A.; Bag, S.; Grigalunas, M.; Woitalla, S.; Bodenbinder, P.-J.; Brieger, L.; Strohmann, C.; Pahl, A.; Sievers, S.; Waldmann, H.: Synthesis of Indofulvin Pseudo-Natural Products Yields a New Autophagy Inhibitor Chemotype. Advanced Science 8 (19), e2102042, pp. 1 - 10 (2021)

Liu, J.; Flegel, J.; Otte, F.; Pahl, A.; Sievers, S.; Strohmann, C.; Waldmann, H.: Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids. Angewandte Chemie International Edition 60 (39), pp. 21384 - 21395 (2021)

Liu, J.; Flegel, J.; Otte, F.; Pahl, A.; Sievers, S.; Strohmann, C.; Waldmann, H.: Combination of Pseudo-Natural Product Design and Formal Natural Product Ring Distortion Yields Stereochemically and Biologically Diverse Pseudo-Sesquiterpenoid Alkaloids. Angewandte Chemie 133 (39), pp. 21554 - 21565 (2021)

Borgelt, L.; Li, F.; Hommen, P.; Lampe, P.; Hwang, J.; Goebel, G. L.; Sievers, S.; Wu, P.: Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein-RNA Interaction of LIN28 and Let-7. ACS Medicinal Chemistry Letters 12 (6), pp. 893 - 898 (2021)

Spinck, M.; Bischoff, M.; Lampe, P.; Meyer-Almes, F.-J.; Sievers, S.; Neumann, H.: Discovery of Dihydro-1,4-Benzoxazine Carboxamides as Potent and Highly Selective Inhibitors of Sirtuin‑1. Journal of Medicinal Chemistry 64 (9), pp. 5838 - 5849 (2021)

Nöcker, C.; Kaiser, N.; Foley, D. J.; Sievers, S.; Janning, P.; Waldmann, H.; Laraia, L.: Thermal proteome profiling efficiently identifies ribosome destabilizing oxazolidinones. Tetrahedron 87, 132118, pp. 1 - 7 (2021)