Publications

Bauer, L. G.; Ward, J. A.; Díaz-Sáez , L.; Sundström, Y.; Tolvanen, T.; Alarcón Barrera, J. C.; Kostidis, S.; Rogers, C. M.; Panagakou, I.; Singh, U. et al.; Rothweiler, E. M.; Gonzalez Orta, A.; Kaniskan, H. Ü.; Hu, J.; Sievers, S.; Waldmann, H.; Giera, M.; Sundström, M.; Berg, L.; Huber, K.: Phenomics-based Discovery of Novel Orthosteric Choline Kinase Inhibitors. Angewandte Chemie, International Edition in English (2024)

Wendrich, K.; Gallant, K.; Recknagel, S.; Petroulia, S.; Haque Kazi, N.; Hane, J. A.; Führer, S.; Bezstarosti, K.; O'Dea, R.; Demmers, J. et al.; Gersch, M.: Discovery and mechanism of K63-linkage-directed deubiquitinase activity in USP53. Nature Chemical Biology (2024)

Lim, W. M.; Chew, W.-X.; Esposito Verza, A.; Pesenti, M.; Musacchio, A.; Surrey, T.: Regulation of minimal spindle midzone organization by mitotic kinases. Nature Communications (2024)

Hedtfeld, M.; Musacchio, A.: Protocol for validating liquid-liquid phase separation as a driver of membraneless organelle assembly in vitro and in human cells. STAR Protoc. (2024)

Heinzke, A. L.; Zdrazil, B.; Leeson, P. D.; Young, R. J.; Pahl, A.; Waldmann, H.; Leach, A. R.: A compound-target pairs dataset: differences between drugs, clinical candidates and other bioactive compounds. Scientific Data (2024)

Jiang, M.; Giannino, N.; Goebel, G. L.; Sievers, S.; Wu, P.: LIN28-Targeting Chromenopyrazoles and Tetrahydroquinolines Induced Cellular Morphological Changes and Showed High Biosimilarity with BRD PROTACs. ChemMedChem (2024)

Fischer, K. D.; Tiwari, S.; Thier, B.; Qiu, L. C.; Lin, T.-C.; Paschen, A.; Imig, J.: Long non-coding RNA GRASLND links melanoma differentiation and interferon-gamma response. Frontiers in Molecular Biosciences (2024)

Pal, S.; Gordijenko, I.; Schmeink , S.; Somarghya, B.; Akbulut, Y.; Gasper, R.; `T Hart, P.: Stapled Peptides as Inhibitors of mRNA Deadenylation. Angewandte Chemie, International Edition in English (2024)

Conti, D.; Esposito Verza, A.; Pesenti, M.; Cmentowski, V.; Vetter, I. R.; Pan, D.; Musacchio, A.: Role of protein kinase PLK1 in the epigenetic maintenance of centromeres. Science (2024)

Cheng, X.-F.; Grigalunas, M.; Waldmann, H.: Progress and opportunities of pseudo-natural-product design in molecular discovery. ARKIVOC (2024)

Rezaei Adariani, S.; Agne, D.; Koska, S.; Burhop, A.; Seitz, C.; Warmers, J.; Janning, P.; Metz, M.; Pahl, A.; Sievers, S. et al.; Waldmann, H.; Ziegler, S.: Detection of a Mitochondrial Fragmentation and Integrated Stress Response Using the Cell Painting Assay. Journal of Medicinal Chemistry (2024)

Heinzke, A. L.; Pahl, A.; Zdrazil, B.; Leach, A. R.; Waldmann, H.; Young, R. J.; Leeson, P. D.: Occurrence of "Natural Selection" in Successful Small Molecule Drug Discovery. Journal of Medicinal Chemistry 67 (13), pp. 11226 - 11241 (2024)

Pahl, A.; Grygorenko, O. O.; Konratov, I. O.; Waldmann, H.: Identification of readily available pseudo-natural products. RSC Medicinal Chemistry (2024)

Cigler, M.; Imrichova, H.; Frommelt, F.; Caramelle, L.; Depta, L.; Rukavina, A.; Kagiou, C.; Hannich, T.; Mayor-Ruiz, C.; Superti-Furga, G. et al.; Sievers, S.; Forrester, A.; Laraia, L.; Waldmann, H.; Winter, G.: Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP. Nature Chemical Biology (2024)

Schumacher, S.; Fernkorn, M.; Marten, M.; Chen, R.; Kim, Y. S.; Bedzhov, I.; Schröter, C.: Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation. Nature Communications (2024)